Duggan-Keen M, Roberts D F, Wentzel J
Acta Neurol Scand. 1987 Mar;75(3):218-20. doi: 10.1111/j.1600-0404.1987.tb07921.x.
In vitro lymphocyte proliferation in response to allogeneic pooled cells, phytohaemaglutinin (PHA), and pokeweed mitogen (PWM), was measured in relation to HLA A, B and C status in 67 patients with clinically definite multiple sclerosis and in 67 age- and sex-matched controls. Analysis of covariance taking age into account showed significant effects only for A9 and B12 in controls and B27 and Cw3 in patients, fewer than would be expected by chance. It is concluded that HLA Class 1 status is not an important factor in regulating mitogen responsiveness.
在67例临床确诊的多发性硬化症患者及67例年龄和性别匹配的对照者中，检测了针对同种异体混合细胞、植物血凝素（PHA）和商陆有丝分裂原（PWM）的体外淋巴细胞增殖情况，并将其与HLA A、B和C状态相关联。考虑年龄因素的协方差分析显示，仅对照组中的A9和B12以及患者组中的B27和Cw3有显著影响，低于偶然预期。得出的结论是，HLA I类状态不是调节有丝分裂原反应性的重要因素。
