Balibrea J L, Gomez J, Aznar J, Alemany J R, Ruiz J, Fernandez J L, Campos J M, Barreno P G, Avila L
Eur Surg Res. 1979;11(1):8-14. doi: 10.1159/000128047.
The effects of continuous intravenous perfusion of somatostatin on the incidence of ulcers and the histamine and serotonin gastric mucosal content in rats subjected to 12 h of restraint were studied. 51 sets of Sprague-Dawley male rats (102 animals) were divided at random into two groups. Those in group I were immobilized and treated with an intravenous infusion of isotonic saline solution. Animals in group II were also immobilized and given intravenous cyclic somatostatin dissolved in isotonic saline solution; the initial dose was 25 microgram and a continuous infusion of 2.5 microgram/kg/h was administered thereafter. A decrease in the ulcer index was observed in the rats perfused with somatostatin (p less than 0.01) as well as a decrease in the histamine (p less than 0.001) and serotonin (p less than 0.01) gastric mucosal contents. These effects of somatostatin on restraint-induced stress ulcer in rats are probably to be explained by microcirculatory changes in the gastric mucosa determined by the vasoactive amines (histamine and serotonin). They constitute an important factor in the pathogenesis of these lesions.
研究了连续静脉灌注生长抑素对经12小时束缚的大鼠溃疡发生率以及胃黏膜组胺和血清素含量的影响。将51组斯普拉格-道利雄性大鼠（102只动物）随机分为两组。第一组大鼠被束缚并静脉输注等渗盐溶液。第二组大鼠同样被束缚，并静脉给予溶于等渗盐溶液的环状生长抑素；初始剂量为25微克，随后以2.5微克/千克/小时的速度持续输注。观察到灌注生长抑素的大鼠溃疡指数降低（p<0.01），同时胃黏膜组胺（p<0.001）和血清素（p<0.01）含量也降低。生长抑素对大鼠束缚诱导的应激性溃疡的这些作用可能是由血管活性胺（组胺和血清素）决定的胃黏膜微循环变化所解释的。它们是这些病变发病机制中的一个重要因素。
