Hirvonen J, Huttunen P, Martimo K P, Puurunen J
Z Rechtsmed. 1983;90(4):239-46. doi: 10.1007/BF02116198.
The effect on rat gastric mucosa of ethanol and acetylsalicylic acid given at two doses singly or in combination were studied by administering the drugs into the stomach. 40% ethanol alone caused many ulcerations after 5 h, and the effect was even more marked with simultaneous administration of acetylsalicylic acid (ASA). 10% ethanol and 50 mg ASA/kg b. wt. were tolerated well. The mucosal lesions consisted of coagulation necrosis and hemorrhages, with a disappearance of histamine and serotonin from the mucosal mast cells in and around the lesion.
通过将药物经胃给药，研究了单剂量及联合使用两种剂量的乙醇和乙酰水杨酸对大鼠胃黏膜的影响。单独给予40%乙醇5小时后会导致许多溃疡，同时给予乙酰水杨酸（ASA）时效果更明显。10%乙醇和50mg ASA/kg体重能被很好地耐受。黏膜损伤包括凝固性坏死和出血，损伤部位及周围黏膜肥大细胞中的组胺和5-羟色胺消失。
