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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Caccia S, Cecchetti G, Garattini S, Jori A

Br J Pharmacol. 1973 Nov;49(3):400-6. doi: 10.1111/j.1476-5381.1973.tb17250.x.

(+)-Amphetamine sulphate elicits a dose-dependent hyperthermia in NMRI mice but it does not significantly increase the body temperature of C(3)H mice.2. When low doses of (+)-amphetamine are given, the body temperature of C(3)H mice decreases.3. (+)-Amphetamine decreases the noradrenaline concentration in the brain-stem and increases the homovanillic acid concentration (HVA) in the striatum of NMRI mice, but only slightly reduces the noradrenaline concentration and does not change the HVA concentration in the brains of C(3)H mice.4. The two strains appear to show a difference in the metabolism of dopamine in the striatum. The rates at which dopamine disappears from the tissue after blocking catecholamine synthesis with alpha-methyltyrosine and the rates at which HVA accumulates after blocking the active transport of this metabolite out of the brain with probenecid suggest that the turnover of dopamine is lower in C(3)H mice than in NMRI mice.

硫酸（+）-苯丙胺在NMRI小鼠中引发剂量依赖性体温升高，但对C3H小鼠的体温没有显著影响。2. 给予低剂量的（+）-苯丙胺时，C3H小鼠的体温会降低。3. （+）-苯丙胺降低了NMRI小鼠脑干中的去甲肾上腺素浓度，并增加了纹状体中的高香草酸浓度（HVA），但仅略微降低了C3H小鼠脑中的去甲肾上腺素浓度，且未改变其HVA浓度。4. 这两个品系在纹状体中多巴胺的代谢方面似乎存在差异。在用α-甲基酪氨酸阻断儿茶酚胺合成后多巴胺从组织中消失的速率，以及在用丙磺舒阻断这种代谢产物从脑中的主动转运后HVA积累的速率表明，C3H小鼠中多巴胺的周转率低于NMRI小鼠。

Caccia S, Cecchetti G, Garattini S, Jori A

Br J Pharmacol. 1973 Nov;49(3):400-6. doi: 10.1111/j.1476-5381.1973.tb17250.x.

(+)-Amphetamine sulphate elicits a dose-dependent hyperthermia in NMRI mice but it does not significantly increase the body temperature of C(3)H mice.2. When low doses of (+)-amphetamine are given, the body temperature of C(3)H mice decreases.3. (+)-Amphetamine decreases the noradrenaline concentration in the brain-stem and increases the homovanillic acid concentration (HVA) in the striatum of NMRI mice, but only slightly reduces the noradrenaline concentration and does not change the HVA concentration in the brains of C(3)H mice.4. The two strains appear to show a difference in the metabolism of dopamine in the striatum. The rates at which dopamine disappears from the tissue after blocking catecholamine synthesis with alpha-methyltyrosine and the rates at which HVA accumulates after blocking the active transport of this metabolite out of the brain with probenecid suggest that the turnover of dopamine is lower in C(3)H mice than in NMRI mice.

硫酸（+）-苯丙胺在NMRI小鼠中引发剂量依赖性体温升高，但对C3H小鼠的体温没有显著影响。2. 给予低剂量的（+）-苯丙胺时，C3H小鼠的体温会降低。3. （+）-苯丙胺降低了NMRI小鼠脑干中的去甲肾上腺素浓度，并增加了纹状体中的高香草酸浓度（HVA），但仅略微降低了C3H小鼠脑中的去甲肾上腺素浓度，且未改变其HVA浓度。4. 这两个品系在纹状体中多巴胺的代谢方面似乎存在差异。在用α-甲基酪氨酸阻断儿茶酚胺合成后多巴胺从组织中消失的速率，以及在用丙磺舒阻断这种代谢产物从脑中的主动转运后HVA积累的速率表明，C3H小鼠中多巴胺的周转率低于NMRI小鼠。