对两种近交系小鼠对右旋苯丙胺热反应的遗传分析。
A genetic analysis of the hyperthermic response to d-amphetamine in two inbred strains of mice.
作者信息
Jori A, Rutczynski M
出版信息
Psychopharmacology (Berl). 1978 Oct 31;59(2):199-203. doi: 10.1007/BF00427758.
PMID:103123
Abstract
A genetic analysis of amphetamine-induced hyperthermia was conducted in inbred mice of the strains Balb/c and C3H and in their F1F2 and backcross generations. The results of biometric analysis indicate that the effect of amphetamine on body temperature is genetically determined. The mode of inheritance characterized by a partial dominance (Balb/C over C3H strain). However, a possible maternal effect of C3H can overcome the dominant effect in male progenies and inhibit amphetamine hyperthermic effect.
摘要
对Balb/c和C3H品系的近交系小鼠及其F1、F2和回交后代进行了苯丙胺诱导的体温过高的遗传分析。生物统计学分析结果表明，苯丙胺对体温的影响是由基因决定的。遗传模式的特点是部分显性（Balb/C品系相对于C3H品系）。然而，C3H可能存在的母体效应可以克服雄性后代中的显性效应，并抑制苯丙胺的体温过高效应。
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