鸡羊膜肌中毒蕈碱受体的数量。
The number of muscarinic receptors in chick amnion muscle.
作者信息
Cuthbert A W, Young J M
出版信息
Br J Pharmacol. 1973 Nov;49(3):498-505. doi: 10.1111/j.1476-5381.1973.tb17260.x.
Abstract
- [(3)H]-Propyl benzilylcholine mustard ([(3)H]-PrBCM) an irreversible specific antagonist of muscarinic acetylcholine receptors, has been used to label the muscarinic receptors in the aneuronal muscle of isolated 11 day amniotic membranes of chick embryos.2. This muscle was found to have about 9 fmol/mg dry weight of receptor material. This is only 1-2% of the amount found in intestinal muscle.3. Pharmacological studies with isolated amniotic membranes using PrBCM show that labelling is to functional receptors and that the receptor reserve is small.4. The significance of the difference in receptor reserve in innervated and aneuronal plain muscle is discussed.
摘要
[（3）H]-丙基苄基胆碱氮芥（[(3)H]-PrBCM）是一种毒蕈碱型乙酰胆碱受体的不可逆特异性拮抗剂，已被用于标记鸡胚11天分离羊膜无神经肌肉中的毒蕈碱受体。
发现这种肌肉中受体物质的含量约为9飞摩尔/毫克干重。这仅为肠肌中发现量的1%-2%。
使用PrBCM对分离羊膜进行的药理学研究表明，标记的是功能性受体，且受体储备较小。
讨论了神经支配的平滑肌和无神经平滑肌中受体储备差异的意义。
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本文引用的文献
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THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS.豚鼠肠道平滑肌对阿托品及相关药物的摄取与乙酰胆碱受体的关系
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ELECTRICAL ACTIVITY OF THE SMOOTH MUSCLE OF THE CHICK AMNION.鸡羊膜平滑肌的电活动
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STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE.挥发性麻醉药对平滑肌的兴奋作用
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SOME EFFECTS OF ATROPINE ON SMOOTH MUSCLE.阿托品对平滑肌的某些作用。
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Br J Pharmacol Chemother. 1962 Jun;18(3):550-62. doi: 10.1111/j.1476-5381.1962.tb01174.x.
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Biochem Pharmacol. 1962 Feb;11:113-23. doi: 10.1016/0006-2952(62)90098-9.
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Br J Pharmacol. 1971 Oct;43(2):417P-418P.
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