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鸡羊膜肌中毒蕈碱受体的数量。

The number of muscarinic receptors in chick amnion muscle.

作者信息

Cuthbert A W, Young J M

出版信息

Br J Pharmacol. 1973 Nov;49(3):498-505. doi: 10.1111/j.1476-5381.1973.tb17260.x.

DOI:10.1111/j.1476-5381.1973.tb17260.x
PMID:4777709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776480/
Abstract
  1. [(3)H]-Propyl benzilylcholine mustard ([(3)H]-PrBCM) an irreversible specific antagonist of muscarinic acetylcholine receptors, has been used to label the muscarinic receptors in the aneuronal muscle of isolated 11 day amniotic membranes of chick embryos.2. This muscle was found to have about 9 fmol/mg dry weight of receptor material. This is only 1-2% of the amount found in intestinal muscle.3. Pharmacological studies with isolated amniotic membranes using PrBCM show that labelling is to functional receptors and that the receptor reserve is small.4. The significance of the difference in receptor reserve in innervated and aneuronal plain muscle is discussed.
摘要
  1. [(3)H]-丙基苄基胆碱氮芥([(3)H]-PrBCM)是一种毒蕈碱型乙酰胆碱受体的不可逆特异性拮抗剂,已被用于标记鸡胚11天分离羊膜无神经肌肉中的毒蕈碱受体。

  2. 发现这种肌肉中受体物质的含量约为9飞摩尔/毫克干重。这仅为肠肌中发现量的1%-2%。

  3. 使用PrBCM对分离羊膜进行的药理学研究表明,标记的是功能性受体,且受体储备较小。

  4. 讨论了神经支配的平滑肌和无神经平滑肌中受体储备差异的意义。

相似文献

1
The number of muscarinic receptors in chick amnion muscle.鸡羊膜肌中毒蕈碱受体的数量。
Br J Pharmacol. 1973 Nov;49(3):498-505. doi: 10.1111/j.1476-5381.1973.tb17260.x.
2
Muscarinic receptors in rat intestinal muscle: comparison with the guinea pig.大鼠肠肌中的毒蕈碱受体:与豚鼠的比较。
Eur J Pharmacol. 1975 Apr;31(2):319-26. doi: 10.1016/0014-2999(75)90055-2.
3
Determination of the number of muscarinic receptors in chick amnion muscle.鸡羊膜肌中毒蕈碱受体数量的测定。
Br J Pharmacol. 1973 Mar;47(3):631P-632P.
4
The binding of (3H)-propylbenzilycholine mustard by longitudinal muscle strips from guinea-pig small intestine.豚鼠小肠纵行肌条对(3H)-丙基苯甲酰胆碱氮芥的结合
Br J Pharmacol. 1974 Jan;50(1):145-51. doi: 10.1111/j.1476-5381.1974.tb09602.x.
5
The properties of muscarinic receptors in mammalian cerebral cortex.哺乳动物大脑皮层中毒蕈碱受体的特性。
Br J Pharmacol. 1974 Jun;51(2):279-85. doi: 10.1111/j.1476-5381.1974.tb09658.x.
6
Proceedings: Two populations of acetylcholine receptors in guinea-pig ileum.论文:豚鼠回肠中的两类乙酰胆碱受体
Br J Pharmacol. 1974 May;51(1):127P.
7
Interaction of benzilylcholine mustard, benzilylcholine and lachesine with the histamine receptor in the longitudinal muscle of guinea-pig ileum.苯甲酰胆碱氮芥、苯甲酰胆碱和拉切辛与豚鼠回肠纵肌中组胺受体的相互作用。
Br J Pharmacol. 1973 May;48(1):148-55. doi: 10.1111/j.1476-5381.1973.tb08233.x.
8
The distribution of muscarinic receptor sites in the nervous system of the dog.毒蕈碱受体位点在犬神经系统中的分布。
J Neurochem. 1974 Jan;22(1):159-62. doi: 10.1111/j.1471-4159.1974.tb12192.x.
9
The irreversible binding of acetylcholine mustard to muscarinic receptors in intestinal smooth muscle of the guinea-pig.乙酰胆碱芥子气与豚鼠肠道平滑肌中毒蕈碱受体的不可逆结合。
Br J Pharmacol. 1975 Mar;53(3):363-70. doi: 10.1111/j.1476-5381.1975.tb07372.x.
10
The conversion of methyl-2-acetoxyethyl-2'-chloroethylamine to an acetylcholine-like aziridinium ion and its action on the isolated guinea pig ileum.2-乙酰氧基乙基-2'-氯乙胺转化为类似乙酰胆碱的氮丙啶离子及其对离体豚鼠回肠的作用。
Can J Physiol Pharmacol. 1972 Aug;50(8):798-808. doi: 10.1139/y72-116.

引用本文的文献

1
Mechanisms for the effects of acetylcholine on sodium transport in frog skin.乙酰胆碱对蛙皮钠转运影响的机制。
J Membr Biol. 1981 Mar 15;59(1):65-75. doi: 10.1007/BF01870822.
2
Expression of functional neurotransmitter receptors in an uninnervated tissue: avian amnion.
Cell Tissue Res. 1989 Nov;258(2):409-15. doi: 10.1007/BF00239462.
3
The irreversible binding of acetylcholine mustard to muscarinic receptors in intestinal smooth muscle of the guinea-pig.乙酰胆碱芥子气与豚鼠肠道平滑肌中毒蕈碱受体的不可逆结合。
Br J Pharmacol. 1975 Mar;53(3):363-70. doi: 10.1111/j.1476-5381.1975.tb07372.x.

本文引用的文献

1
THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS.豚鼠肠道平滑肌对阿托品及相关药物的摄取与乙酰胆碱受体的关系
Proc R Soc Lond B Biol Sci. 1965 Aug 24;163:1-44. doi: 10.1098/rspb.1965.0058.
2
ELECTRICAL ACTIVITY OF THE SMOOTH MUSCLE OF THE CHICK AMNION.鸡羊膜平滑肌的电活动
J Physiol. 1964 Aug;172(2):264-73. doi: 10.1113/jphysiol.1964.sp007416.
3
STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE.挥发性麻醉药对平滑肌的兴奋作用
Br J Pharmacol Chemother. 1964 Apr;22(2):356-65. doi: 10.1111/j.1476-5381.1964.tb02040.x.
4
SOME EFFECTS OF ATROPINE ON SMOOTH MUSCLE.阿托品对平滑肌的某些作用。
Br J Pharmacol Chemother. 1963 Oct;21(2):285-94. doi: 10.1111/j.1476-5381.1963.tb01527.x.
5
Actions of some anticholinesterases on the smooth muscle of the chick amnion.某些抗胆碱酯酶对鸡羊膜平滑肌的作用。
Br J Pharmacol Chemother. 1962 Jun;18(3):550-62. doi: 10.1111/j.1476-5381.1962.tb01174.x.
6
Cholinesterases in the domestic fowl and the specificity of some reversible inhibitors.家禽体内的胆碱酯酶及某些可逆性抑制剂的特异性
Biochem Pharmacol. 1962 Feb;11:113-23. doi: 10.1016/0006-2952(62)90098-9.
7
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
8
Membrane growth and function.膜的生长与功能。
Ann N Y Acad Sci. 1952 Aug 8;55(2):288-301. doi: 10.1111/j.1749-6632.1952.tb26545.x.
9
An alkylating derivative of benzilylcholine with specific and long-lasting parasympatholytic activity.一种具有特异性和长效副交感神经阻滞活性的苄基胆碱烷基化衍生物。
Mol Pharmacol. 1966 Jul;2(4):284-97.
10
Distribution of bound 3 H-benzilylcholine mustard in subcellular fractions of smooth muscle from guinea-pig ileum.豚鼠回肠平滑肌亚细胞组分中结合的3H-苄基胆碱氮芥的分布
Br J Pharmacol. 1971 Oct;43(2):417P-418P.