Acid phosphatase in normal human blood cells: characterization by isoelectric focusing in polyacrylamide gel.

Using the high resolution technique of isoelectric focusing in polyacrylamide gel, isoenzymatic components could be discerned in acid phosphatase extracted from normal human lymphocytes, granulocytes, monocytes, and platelets. For each cell type, distinctive isoenzymatic patterns of acid phosphatase activity could be observed. These studies provide further evidence that various types of cellular differentiation are associated with differences in isoenzymatic components of acid phosphatase.