多胎妊娠时母体血清甲胎蛋白水平

Maternal serum alpha-fetoprotein levels in multiple pregnancy.

作者信息

Wald N, Barker S, Peto R, Brock D J, Bonnar J

出版信息

Br Med J. 1975 Mar 22;1(5959):651-2. doi: 10.1136/bmj.1.5959.651.

DOI:10.1136/bmj.1.5959.651

PMID:47778

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1672896/

Abstract

Maternal serum alpha-fetoprotein (AFP) levels were higher in 10 twin pregnancies and one triplet pregnancy than in 22 control singleton pregnancies matched for maternal age, parity, and the time of gestation at which the serum sample was taken. In twin pregnancies the average AFP levels were double those found in singleton pregnancies and the level in the triplet pregnancy was even higher. Raised maternal serum AFP values due to multiple pregnancy should not cause unnecessary amniocentesis in the diagnosis of anencephaly or spina bifida if an ultrasound investigation is routinely performed first.

摘要

10例双胎妊娠和1例三胎妊娠孕妇血清甲胎蛋白（AFP）水平高于22例与孕妇年龄、产次及血清样本采集时孕周相匹配的对照单胎妊娠孕妇。在双胎妊娠中，AFP平均水平是单胎妊娠的两倍，三胎妊娠中的水平更高。如果首先常规进行超声检查，多胎妊娠导致的孕妇血清AFP值升高在无脑儿或脊柱裂的诊断中不应引起不必要的羊膜穿刺术。

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Alpha-feto-protein during development and in disease.发育过程及疾病中的甲胎蛋白。

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本文引用的文献

1

Alpha fetoprotein and human placental lactogen levels in maternal serum in multiple pregnancies.多胎妊娠孕妇血清中甲胎蛋白和人胎盘催乳素水平

J Obstet Gynaecol Br Commonw. 1973 Aug;80(8):695-700. doi: 10.1111/j.1471-0528.1973.tb16052.x.

2

Causation of neural tube defects: clues from epidemiology.神经管缺陷的病因：来自流行病学的线索

Br Med Bull. 1974 May;30(2):158-63. doi: 10.1093/oxfordjournals.bmb.a071187.

3

Prenatal diagnosis of spina bifida and anencephaly through maternal plasma-alpha-fetoprotein measurement.通过母体血浆甲胎蛋白检测对脊柱裂和无脑儿进行产前诊断。

Lancet. 1974 Apr 27;1(7861):767-9. doi: 10.1016/s0140-6736(74)92839-6.

4

Prenatal diagnosis of spina bifida and anencephaly by maternal serum-alpha-fetoprotein measurement. A controlled study.通过母体血清甲胎蛋白测量对脊柱裂和无脑儿进行产前诊断。一项对照研究。

Lancet. 1974 Apr 27;1(7861):765-7. doi: 10.1016/s0140-6736(74)92838-4.

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Letter: Alpha-fetoprotein in twin pregnancy.

Lancet. 1973 Nov 24;2(7839):1214. doi: 10.1016/s0140-6736(73)92989-9.

6

Radioimmunoassay of maternal serum alpha fetoprotein during pregnancy and delivery.孕期及分娩期间母血甲胎蛋白的放射免疫测定

Am J Obstet Gynecol. 1972 Jan 15;112(2):208-12. doi: 10.1016/0002-9378(72)90117-2.

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