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1
Maternal serum alpha-fetoprotein levels in multiple pregnancy.多胎妊娠时母体血清甲胎蛋白水平
Br Med J. 1975 Mar 22;1(5959):651-2. doi: 10.1136/bmj.1.5959.651.
2
Maternal serum-alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Report of U.K. collaborative study on alpha-fetoprotein in relation to neural-tube defects.孕早期产前筛查无脑儿和脊柱裂时母体血清甲胎蛋白测定。英国甲胎蛋白与神经管缺陷相关协作研究报告。
Lancet. 1977 Jun 25;1(8026):1323-32.
3
Maternal serum alpha-fetoprotein and previous neural tube defects.孕妇血清甲胎蛋白与既往神经管缺陷
Br J Obstet Gynaecol. 1976 Mar;83(3):213-6. doi: 10.1111/j.1471-0528.1976.tb00811.x.
4
Amniotic fluid alpha-fetoprotein as a marker in prenatal diagnosis of neural tube defects.羊水甲胎蛋白作为神经管缺陷产前诊断的标志物。
Obstet Gynecol. 1976 Feb;47(2):148-51.
5
A semi-automated serum alphafetoprotein radioimmunoassay for prenatal spina bifida screening.一种用于产前脊柱裂筛查的半自动血清甲胎蛋白放射免疫测定法。
Br J Obstet Gynaecol. 1975 Sep;82(9):718-27. doi: 10.1111/j.1471-0528.1975.tb00712.x.
6
The significance of raised maternal serum alpha-fetoprotein levels.
Br J Obstet Gynaecol. 1976 Nov;83(11):845-52. doi: 10.1111/j.1471-0528.1976.tb00758.x.
7
Maternal serum alpha-fetoprotein levels in triplet and quadruplet pregnancy.
Br J Obstet Gynaecol. 1978 Feb;85(2):124-6. doi: 10.1111/j.1471-0528.1978.tb10465.x.
8
Evaluation of measurement of maternal plasma alpha-fetoprotein levels as a screening test for fetal neural tube defects.评估孕妇血浆甲胎蛋白水平测量作为胎儿神经管缺陷筛查试验的效果。
Br J Obstet Gynaecol. 1977 Aug;84(8):574-7. doi: 10.1111/j.1471-0528.1977.tb12655.x.
9
Amniotic fluid concentrations of alpha-fetoprotein (AFP) in early normal pregnancy, and pregnancy complicated by neural tube defects. A review of 18 months experience.正常妊娠早期及合并神经管缺陷妊娠时羊水甲胎蛋白（AFP）的浓度。18个月经验回顾。
Guys Hosp Rep. 1974;123(2):121-9.
10
[Prenatal diagnosis of anencephaly and spina bifida. Determination of alphafetoprotein in amniotic fluid and serum in the 16th-24th gestational week].[无脑儿和脊柱裂的产前诊断。孕16至24周时羊水和血清中甲胎蛋白的测定]
Ugeskr Laeger. 1975 Jul 21;137(30):1703-6.

引用本文的文献

1
Maternal Serum α-Fetoprotein Levels during Pregnancy and Testicular Cancer in Male Offspring: A Cohort Study within a Danish Pregnancy Screening Registry.孕期母体血清甲胎蛋白水平与男性子代睾丸癌的关系：丹麦孕期筛查登记处的队列研究。
Int J Environ Res Public Health. 2022 Oct 28;19(21):14112. doi: 10.3390/ijerph192114112.
2
Serum alpha feto-protein screening in high risk pregnancies.高危妊娠中的血清甲胎蛋白筛查。
Indian J Pediatr. 1995 Jan-Feb;62(1):101-7. doi: 10.1007/BF02752193.
3
Maternal serum alpha-fetoprotein screening for neural tube defects. Report of a combined study in Germany and short overview on screening in populations with low birth prevalence of neural tube defects.用于神经管缺陷的母血清甲胎蛋白筛查。德国一项联合研究的报告及神经管缺陷低出生患病率人群筛查的简短概述。
Hum Genet. 1985;69(1):47-61. doi: 10.1007/BF00295529.
4
Alphafetoprotein and neural tube defects.甲胎蛋白与神经管缺陷
J Clin Pathol Suppl (R Coll Pathol). 1976;10:157-64.
5
Alpha-feto-protein during development and in disease.发育过程及疾病中的甲胎蛋白。
J Med Genet. 1975 Jun;12(2):138-51. doi: 10.1136/jmg.12.2.138.

本文引用的文献

1
Alpha fetoprotein and human placental lactogen levels in maternal serum in multiple pregnancies.多胎妊娠孕妇血清中甲胎蛋白和人胎盘催乳素水平
J Obstet Gynaecol Br Commonw. 1973 Aug;80(8):695-700. doi: 10.1111/j.1471-0528.1973.tb16052.x.
2
Causation of neural tube defects: clues from epidemiology.神经管缺陷的病因：来自流行病学的线索
Br Med Bull. 1974 May;30(2):158-63. doi: 10.1093/oxfordjournals.bmb.a071187.
3
Prenatal diagnosis of spina bifida and anencephaly through maternal plasma-alpha-fetoprotein measurement.通过母体血浆甲胎蛋白检测对脊柱裂和无脑儿进行产前诊断。
Lancet. 1974 Apr 27;1(7861):767-9. doi: 10.1016/s0140-6736(74)92839-6.
4
Prenatal diagnosis of spina bifida and anencephaly by maternal serum-alpha-fetoprotein measurement. A controlled study.通过母体血清甲胎蛋白测量对脊柱裂和无脑儿进行产前诊断。一项对照研究。
Lancet. 1974 Apr 27;1(7861):765-7. doi: 10.1016/s0140-6736(74)92838-4.
5
Letter: Alpha-fetoprotein in twin pregnancy.
Lancet. 1973 Nov 24;2(7839):1214. doi: 10.1016/s0140-6736(73)92989-9.
6
Radioimmunoassay of maternal serum alpha fetoprotein during pregnancy and delivery.孕期及分娩期间母血甲胎蛋白的放射免疫测定
Am J Obstet Gynecol. 1972 Jan 15;112(2):208-12. doi: 10.1016/0002-9378(72)90117-2.

多胎妊娠时母体血清甲胎蛋白水平

Maternal serum alpha-fetoprotein levels in multiple pregnancy.

作者信息

Wald N, Barker S, Peto R, Brock D J, Bonnar J

出版信息

Br Med J. 1975 Mar 22;1(5959):651-2. doi: 10.1136/bmj.1.5959.651.

DOI:10.1136/bmj.1.5959.651
PMID:47778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1672896/
Abstract

Maternal serum alpha-fetoprotein (AFP) levels were higher in 10 twin pregnancies and one triplet pregnancy than in 22 control singleton pregnancies matched for maternal age, parity, and the time of gestation at which the serum sample was taken. In twin pregnancies the average AFP levels were double those found in singleton pregnancies and the level in the triplet pregnancy was even higher. Raised maternal serum AFP values due to multiple pregnancy should not cause unnecessary amniocentesis in the diagnosis of anencephaly or spina bifida if an ultrasound investigation is routinely performed first.

摘要

10例双胎妊娠和1例三胎妊娠孕妇血清甲胎蛋白（AFP）水平高于22例与孕妇年龄、产次及血清样本采集时孕周相匹配的对照单胎妊娠孕妇。在双胎妊娠中，AFP平均水平是单胎妊娠的两倍，三胎妊娠中的水平更高。如果首先常规进行超声检查，多胎妊娠导致的孕妇血清AFP值升高在无脑儿或脊柱裂的诊断中不应引起不必要的羊膜穿刺术。