囊性纤维化患者及其父母和兄弟姐妹的血清甲胎蛋白水平。
Serum alpha - fetoprotein levels in patients with cystic fibrosis and their parents and siblings.
作者信息
Chandra R K, Madhavankutty K, Way R C
出版信息
Br Med J. 1975 Mar 29;1(5960):714-6. doi: 10.1136/bmj.1.5960.714.
Abstract
Patients with cystic fibrosis (C.F.) showed raised serum levels of alpha-fetoprotein (AFP). A moderate but significant increase in serum AFP was present in their parents and some siblings. There was no correlation between the clinical severity of the disease and serum AFP concentration. Samples from control groups with gluten-induced malabsorption and bronchiectasis had normal levels. Persistent synthesis of AFP may be an associated marker of C.F. genes, and estimation of serum AFP might help in detecting heterozygote carriers in families at risk.
摘要
囊性纤维化（C.F.）患者血清甲胎蛋白（AFP）水平升高。其父母及部分兄弟姐妹的血清AFP有中度但显著的升高。疾病的临床严重程度与血清AFP浓度之间无相关性。患有麸质诱导吸收不良和支气管扩张的对照组样本AFP水平正常。AFP的持续合成可能是C.F.基因的一个相关标志物，血清AFP的测定可能有助于在有风险的家庭中检测杂合子携带者。
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