3-脱氧-3-氟-D-葡萄糖与人红细胞己糖转运系统的相互作用。
The interaction of 3-deoxy-3-fluoro-D-glucose with the hexose-transport system of the human erythrocyte.
作者信息
Riley G J, Taylor N F
出版信息
Biochem J. 1973 Dec;135(4):773-7. doi: 10.1042/bj1350773.
Abstract
- By using an optical method the kinetic parameters of hexose transport across the human erythrocyte membrane were determined for several sugars. The series of half-saturated constants is as follows: 3-deoxy-3-fluoro-d-glucose = 3-O-methyl-d-glucose <d-glucose<d-mannose <3-deoxy-d-glucose<d-galactose<l-arabinose. 2. Estimations of the dissociation energy of the 3-deoxy-3-fluoro-d-glucose-carrier and d-glucose-carrier complexes suggest that the binding of the two sugars to the transport system is equivalent. 3. Incubation of the erythrocytes with 3-deoxy-3-fluoro-d-glucose results in a small but significant release of F(-) anion. Cells treated in this way lose their ability to transport glucose.
摘要
- 通过光学方法测定了几种糖类跨人红细胞膜转运的动力学参数。半饱和常数系列如下：3-脱氧-3-氟-D-葡萄糖 = 3-O-甲基-D-葡萄糖 < D-葡萄糖 < D-甘露糖 < 3-脱氧-D-葡萄糖 < D-半乳糖 < L-阿拉伯糖。2. 对3-脱氧-3-氟-D-葡萄糖-载体和D-葡萄糖-载体复合物解离能的估计表明，这两种糖与转运系统的结合是等效的。3. 红细胞与3-脱氧-3-氟-D-葡萄糖一起孵育会导致少量但显著的F(-)阴离子释放。以这种方式处理的细胞失去了转运葡萄糖的能力。
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