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大鼠脑中三磷酸腺苷(ATP)的拓扑分布。

Topographical distribution of ATP in rat brain.

作者信息

Wu P H, Moore K C, Phillis J W

出版信息

Experientia. 1979 Jul 15;35(7):881-3. doi: 10.1007/BF01955127.

DOI:10.1007/BF01955127
PMID:477839
Abstract

Studies on the distribution of ATP in microdissected segments of the rat brain indicate that the nucleotide is concentrated in gray matter, and especially in the thalamus, hippocampus, entorhinal cortex and sensorimotor cortex. These distribution studies in conjunction with previous neuropharmacological studies, support the concept that adenine nucleotides may function as intercellular mediators in various regions of the brain.

摘要

对大鼠脑显微切割切片中ATP分布的研究表明,这种核苷酸集中在灰质中,尤其是在丘脑、海马体、内嗅皮质和感觉运动皮质中。这些分布研究与先前的神经药理学研究相结合,支持了腺嘌呤核苷酸可能在脑的各个区域作为细胞间介质发挥作用的概念。

相似文献

1
Topographical distribution of ATP in rat brain.大鼠脑中三磷酸腺苷(ATP)的拓扑分布。
Experientia. 1979 Jul 15;35(7):881-3. doi: 10.1007/BF01955127.
2
Distribution and release of adenosine triphosphate in rat brain.大鼠脑中三磷酸腺苷的分布与释放
Neurochem Res. 1978 Oct;3(5):563-71. doi: 10.1007/BF00963759.
3
Effect of morphine on the RNA and ATP concentration of brain structures of the rat.吗啡对大鼠脑结构中RNA和ATP浓度的影响。
Pharmacology. 1973;10(1):56-9. doi: 10.1159/000136422.
4
The effect of anesthetics on the tissue lactate, pyruvate, phosphocreatine, ATP and AMP concentrations, and on intracellular pH' in the rat brain.
Acta Physiol Scand. 1970 Sep;80(1):142-4. doi: 10.1111/j.1748-1716.1970.tb04778.x.
5
The lactate-pyruvate ratios of cerebrospinal fluid of rats and cats related to the lactate-pyruvate, the ATP-ADP, and the phosphocreatine-creatine ratios of brain tissue.大鼠和猫脑脊液中乳酸与丙酮酸的比值与脑组织中乳酸与丙酮酸、三磷酸腺苷与二磷酸腺苷以及磷酸肌酸与肌酸的比值相关。
Acta Physiol Scand. 1968 Nov;74(3):398-409. doi: 10.1111/j.1748-1716.1968.tb04249.x.
6
Rapid determination of adenine nucleotides in brain tissue by ion-paired reversed-phase column liquid chromatography under isocratic conditions.等度条件下离子对反相柱液相色谱法快速测定脑组织中的腺嘌呤核苷酸
J Chromatogr. 1985 Dec 13;345(2):267-73. doi: 10.1016/0378-4347(85)80164-x.
7
Uneven regional distribution of nucleotide metabolism in human brain.人类大脑中核苷酸代谢的区域分布不均。
Neurobiology (Bp). 1998;6(3):315-21.
8
Effects of alcohol on adenine nucleotide levels of mouse brain.
Q J Stud Alcohol. 1967 Jun;28(2):225-30.
9
The rapid chromatographic analysis of the free nucleotides from rat brain.大鼠脑中游离核苷酸的快速色谱分析
J Chromatogr Sci. 1972 Jan;10(1):38-40. doi: 10.1093/chromsci/10.1.38.
10
[Energy potential of the cerebral cortex in the pre-agonal and post-resuscitation period after acute blood loss].[急性失血后濒死期和复苏后期大脑皮质的能量潜能]
Biull Eksp Biol Med. 1977 Nov;84(11):569-70.

本文引用的文献

1
Free nucleotides of the brain in various mammals.不同哺乳动物大脑中的游离核苷酸。
J Neurochem. 1961 Nov;8:116-25. doi: 10.1111/j.1471-4159.1961.tb13533.x.
2
Free nucleotides in nerve cells. Extraction.神经细胞中的游离核苷酸。提取。
J Neurochem. 1966 Nov;13(11):1257-60. doi: 10.1111/j.1471-4159.1966.tb04285.x.
3
Depression of corticospinal cells by various purines and pyrimidines.各种嘌呤和嘧啶对皮质脊髓细胞的抑制作用。
Can J Physiol Pharmacol. 1974 Dec;52(6):1226-9. doi: 10.1139/y74-162.
4
Purinergic nerves.嘌呤能神经
Pharmacol Rev. 1972 Sep;24(3):509-81.
5
Focussed microwave radiation: a technique to minimize post mortem changes of cyclic nucleotides, dopa and choline and to preserve brain morphology.聚焦微波辐射:一种将死后环核苷酸、多巴和胆碱变化降至最低并保存脑形态的技术。
Neuropharmacology. 1974 Dec;13(12):1115-22. doi: 10.1016/0028-3908(74)90061-6.
6
Stimulation-dependent release of 3H-adenosine derivatives from central axon terminals to target neurones.3H-腺苷衍生物从中枢轴突终末向靶神经元的刺激依赖性释放。
Nature. 1976 Apr 8;260(5551):541-2. doi: 10.1038/260541a0.
7
Purinergic depression of neurons in different areas of the rat brain.大鼠脑不同区域神经元的嘌呤能抑制作用
Exp Neurol. 1977 Jun;55(3 PT. 1):719-24. doi: 10.1016/0014-4886(77)90296-5.
8
Release of ATP from a synaptosomal preparation by elevated extracellular K+ and by veratridine.通过升高细胞外钾离子浓度和藜芦碱从突触体制剂中释放三磷酸腺苷(ATP)。
J Neurochem. 1978 Feb;30(2):329-36. doi: 10.1111/j.1471-4159.1978.tb06534.x.
9
Distribution and release of adenosine triphosphate in rat brain.大鼠脑中三磷酸腺苷的分布与释放
Neurochem Res. 1978 Oct;3(5):563-71. doi: 10.1007/BF00963759.
10
A potent depressant action of adenine derivatives on cerebral cortical neurones.
Eur J Pharmacol. 1975 Jan;30(1):125-9. doi: 10.1016/0014-2999(75)90214-9.