Meshchishetn I F, Iarmol'chuk G M
Farmakol Toksikol. 1979 Jul-Aug;42(4):406-9.
Intramuscular injection of decamin into the animals in a dose of 0.5 and 1 mg/kg has no significant effect on carbohydrate metabolism in the liver of white rats. Decamethoxin and levorin injected in the same doses, specifically in a dose of 1 mg/kg, reduced the level of glucose as well as that of total and free glycogen in the liver. The drugs lowered also the activity of phosphorylase and glocoso-6-phosphatase. Meanwhile the activity of hexokinase, lactate dehydrogenase and phosphoglucosiomerase was potentiated. The animals given decamethoxin showed the aforesaid parameters returning to normal 20 days after the drug was discontinued, whereas similar changes were not found in the rats on levorin.
以0.5毫克/千克和1毫克/千克的剂量给动物肌肉注射地卡明，对大白鼠肝脏中的碳水化合物代谢没有显著影响。以相同剂量，特别是1毫克/千克的剂量注射去甲万古霉素和左旋菌素，会降低肝脏中葡萄糖以及总糖原和游离糖原的水平。这些药物还降低了磷酸化酶和葡萄糖-6-磷酸酶的活性。同时，己糖激酶、乳酸脱氢酶和磷酸葡萄糖异构酶的活性增强。注射去甲万古霉素的动物在停药20天后上述参数恢复正常，而注射左旋菌素的大鼠未发现类似变化。
