Smith U, Digirolamo M, Blohmé G, Kral J G, Tisell L E
Int J Obes. 1980;4(2):153-63.
A patient with Werner's syndrome, partial lipoatrophy and diabetes mellitus presented several of the metabolic alterations found in obesity and maturity-onset diabetes, in spite of a total body-fat mass which was markedly reduced when compared to randomly-selected women. The data show elevated blood sugar and free fatty acids, hyperinsulinemia, elevated glucaon and suppressed growth-hormone levels. Metabolic studies with isolated adipocytes show evidence of increased lipolytic response to catecholamines, diminished binding of insulin and decreased antilipolytic effect of this hormone. A striking feature of this patient's adipose tissue was the contrast between lipoatrophy in the subcutaneous tissue of the extremities and augmented abdominatl subcutaneous adipose tissue. The adipocyte size in this region was very large (1.6 micrograms lipid/cell) and among the largest ever recorded in this laboratory. It is proposed that a 'regional adiposity', particularly in the abdominal area, with enhanced adipocyte size and adipocyte metabolic contributions, may promote the metabolic events and alterations that are more typically observed in the generalized form of obesity.
一名患有沃纳综合征、部分脂肪萎缩和糖尿病的患者，尽管其全身脂肪量与随机选择的女性相比明显减少，但仍出现了肥胖症和成年型糖尿病中常见的几种代谢改变。数据显示血糖和游离脂肪酸升高、高胰岛素血症、胰高血糖素升高以及生长激素水平受到抑制。对分离的脂肪细胞进行的代谢研究表明，脂肪细胞对儿茶酚胺的脂解反应增强、胰岛素结合减少以及该激素的抗脂解作用降低。该患者脂肪组织的一个显著特征是四肢皮下组织的脂肪萎缩与腹部皮下脂肪组织增加形成对比。该区域的脂肪细胞大小非常大（1.6微克脂质/细胞），是本实验室有记录以来最大的之一。有人提出，“局部肥胖”，尤其是腹部区域的肥胖，伴随着脂肪细胞大小的增加和脂肪细胞代谢作用的增强，可能会促进在全身性肥胖中更典型观察到的代谢事件和改变。
