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兔免疫球蛋白同种异型抑制的体液和细胞方面。III. 受抑制动物抗同种异型抗体的产生。

Humoral and cellular aspects of immunologlobulin allotype suppression in the rabbit. III. Production of anti-allotypic antibody by suppressed animals.

作者信息

Lowe J A, Cross L M, Catty D

出版信息

Immunology. 1975 Mar;28(3):469-78.

PMID:47835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445782/
Abstract

Rabbits heterozygous at the 'b' locus (b4b6 or b5b6) were suppressed for b6 production. These suppressed rabbits were immunized to produce anti-allotypic antibody against: (a) determinatns not possessed in their genotype; (b) the suppressed b6 determinants.

摘要

在“b”位点杂合（b4b6或b5b6）的兔子中，b6的产生受到抑制。这些受到抑制的兔子被免疫以产生针对以下物质的抗同种异型抗体：（a）其基因型中不具备的决定簇；（b）被抑制的b6决定簇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f627/1445782/4fbde17da06c/immunology00314-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f627/1445782/4fbde17da06c/immunology00314-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f627/1445782/4fbde17da06c/immunology00314-0088-a.jpg

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Humoral and cellular aspects of immunologlobulin allotype suppression in the rabbit. III. Production of anti-allotypic antibody by suppressed animals.兔免疫球蛋白同种异型抑制的体液和细胞方面。III. 受抑制动物抗同种异型抗体的产生。
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引用本文的文献

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Autoanti-allotype antibodies and idiotypic network regulating allotype production in rabbits.自身抗独特型抗体与调节兔独特型产生的独特型网络。
Immunology. 1985 Dec;56(4):625-33.
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Cellular basis of an auto-anti-allotypic mechanism for the maintenance of chronic allotype suppression in the rabbit.

本文引用的文献

1
Effect of maternal isoantibodies on the quantitative expression of two allelic genes controlling gamma-globulin allotypic specificities.母体同种抗体对控制γ-球蛋白同种异型特异性的两个等位基因定量表达的影响。
Nature. 1962 Aug 18;195:677-80. doi: 10.1038/195677a0.
2
Immunoglobulin allotypes of experimental animals.实验动物的免疫球蛋白同种异型
Prog Allergy. 1967;11:141-84.
3
Humoral and cellular aspects of immunoglobulin allotype suppression in the rabbit. II. Effect of beta locus suppression on immunoglobulin receptor-bearing lymphocytes.
兔慢性同种异型抑制维持中自身抗同种异型机制的细胞基础。
Immunology. 1989 Feb;66(2):238-45.
兔免疫球蛋白同种异型抑制的体液和细胞方面。II. β基因座抑制对携带免疫球蛋白受体淋巴细胞的影响。
Immunology. 1974 Feb;26(2):331-43.
4
Humoral and cellular aspects of immunoglobulin allotype suppression in the rabbit. I. Kinetics of neutralization of suppression.兔免疫球蛋白同种异型抑制的体液和细胞方面。I. 抑制中和的动力学
Immunology. 1973 Sep;25(3):367-75.
5
Active suppression of immunoglobulin allotype synthesis. II. Transfer of suppressing factor with spleen cells.免疫球蛋白同种异型合成的主动抑制。II. 抑制因子与脾细胞的转移。
J Exp Med. 1972 May 1;135(5):1163-76. doi: 10.1084/jem.135.5.1163.
6
Active suppression of immunoglobulin allotype synthesis. 3. Identification of T cells as responsible for suppression by cells from spleen, thymus, lymph node, and bone marrow.免疫球蛋白同种异型合成的主动抑制。3. 鉴定T细胞是脾脏、胸腺、淋巴结和骨髓来源细胞抑制作用的原因。
J Exp Med. 1973 Jun 1;137(6):1311-24. doi: 10.1084/jem.137.6.1311.
7
Suppression of synthesis of allotypically defined immunoglobulins and compensation by another sub-class of immunoglobulin.
Nature. 1967 Jun 24;214(5095):1365-6. doi: 10.1038/2141365a0.