Lowe J A, Catty D
Immunology. 1976 Mar;30(3):335-40.
The injection of anti-b6 antibody into neonatal heterozygous b4b6 or b5b6 rabbits causes allotype suppression. Animals receiving a weight-related dose of antibody on day 2 or day 5 of life showed complete long-term chronic suppression of b6 immunoglobulin. Delay of injection until day 8, day 10 or day 11 of life resulted in more variable suppression, with animals showing either short- or long-term complete suppression or partial suppression. There was some correlation between levels of anti-b6 present in the circulation at day 21 and the degree of suppression obtained. Allotype suppression could be partially neutralized by injection of the paternal type immunoglobulin on days 19, 28, 30 or 43; if the injection was delayed until day 54, 66 or 79 there was no effect and chronic suppression proceeded as in control rabbits not receiving neutralizing immunoglobulin. The results indicate that the critical period for the induction of allotype suppression is between days 11 and 43 of life.
向新生的杂合子b4b6或b5b6兔注射抗b6抗体可导致同种异型抑制。在出生后第2天或第5天接受与体重相关剂量抗体的动物，其b6免疫球蛋白出现完全的长期慢性抑制。将注射延迟至出生后第8天、第10天或第11天，抑制情况则更具变化性，动物表现出短期或长期的完全抑制或部分抑制。出生后第21天循环中抗b6的水平与所获得的抑制程度之间存在一定相关性。在第19天、第28天、第30天或第43天注射父本型免疫球蛋白可部分中和同种异型抑制；如果注射延迟至第54天、第66天或第79天，则没有效果，慢性抑制会像未接受中和免疫球蛋白的对照兔一样继续发展。结果表明，诱导同种异型抑制的关键时期是在出生后第11天至第43天之间。
