Haupt I, Jung H J, Nuske M, Ringelmann R
Immun Infekt. 1979 Jun;7(3):97-102.
To obtain information about the normal range of IgE concentration in serum a random population of male and female patients was divided into 14 age groups. Based on the mean values (x +/- 1s) an age dependency is clearly recognizable with an increase of the IgE concentration at one and two years of age, a constant IgE concentration during the middle age period, and a decrease of the IgE level in the 40th year of age which becomes especially obvious after the 60th and 80th year of age. From the distribution pattern of IgE levels within the different age groups it is evident that only the curves of newborns and persons over 80 years resemble a normal Gaussian distribution. The other age groups show 2 or 3 peaks of IgE. However, these peaks represent only 50% of the total IgE concentration. A similar distribution pattern was obtained by IgE determinations in 100 "healthy" blood donors which showed no clinical evidence of allergy. The age dependent normal ranges given in this paper make it possible to evaluate increased IgE levels accordingly.
为获取血清中IgE浓度的正常范围信息，将随机选取的男女患者群体分为14个年龄组。基于平均值（x +/- 1s），可明显识别出年龄依赖性：一岁和两岁时IgE浓度升高，中年期IgE浓度保持恒定，40岁时IgE水平下降，60岁和80岁后尤为明显。从不同年龄组内IgE水平的分布模式可以看出，只有新生儿和80岁以上人群的曲线类似于正态高斯分布。其他年龄组显示出2个或3个IgE峰值。然而，这些峰值仅占总IgE浓度的50%。在100名无过敏临床证据的“健康”献血者中进行IgE测定，也得到了类似的分布模式。本文给出的年龄依赖性正常范围使得能够相应地评估升高的IgE水平。
