Bakker-Woudenberg I A, van Gerwen A L, Michel M F
Infect Immun. 1979 Jul;25(1):376-87. doi: 10.1128/iai.25.1.376-387.1979.
Pneumococcal pneumonia in rats with intact host defense mechanisms could be successfully cured by penicillin. The efficacy of this antibiotic therapy was lost in cobra venom factor-treated rats which had selectively impaired phagocytic functions. In these animals the effect of penicillin therapy was improved by increasing the daily dose and the frequency of injections and by earlier initiation of the therapy. The efficacy of penicillin in the cobra venom facttor-treated rats was restored either by markedly increasing the daily dose of penicillin or by increasing the daily dose in combination with a reduced interval of the penicillin injections.
在宿主防御机制完整的大鼠中，肺炎球菌肺炎可用青霉素成功治愈。在经眼镜蛇毒因子处理、吞噬功能选择性受损的大鼠中，这种抗生素治疗的效果消失了。在这些动物中，通过增加每日剂量、注射频率以及更早开始治疗，青霉素治疗的效果得到了改善。在经眼镜蛇毒因子处理的大鼠中，要么显著增加青霉素的每日剂量，要么增加每日剂量并缩短青霉素注射间隔时间，青霉素的疗效就能恢复。
