癌症患者的经验性治疗：替卡西林-妥布霉素、替卡西林-头孢噻吩和头孢噻吩-妥布霉素的对比研究。
Empiric therapy for cancer patients: comparative study of ticarcillin-tobramycin, ticarcillin-cephalothin, and cephalothin-tobramycin.
作者信息
Klastersky J, Hensgens C, Debusscher L
出版信息
Antimicrob Agents Chemother. 1975 May;7(5):640-5. doi: 10.1128/AAC.7.5.640.
Abstract
Three combinations of antibiotics (cephalothin-tobramycin, cephalothin-ticarcillin, and ticarcillin-tobramycin) were administered empirically to 186 patients with cancer who were suspected of having a life-threatening infection. In approximately one-half of these patients, gram-negative infection was documented bacteriologically and consisted of septicemia in 50% of these patients. The three antimicrobial regimens were similarly effective and resulted in a favorable clinical response in approximately 55% of the patients. The administration of the cephalothin-tobramycin combination was associated with a significantly higher frequency of nephrotoxicity than that of the other two regimens.
摘要
对186名疑似患有危及生命感染的癌症患者经验性地使用了三种抗生素组合（头孢噻吩-妥布霉素、头孢噻吩-替卡西林和替卡西林-妥布霉素）。在这些患者中，约一半经细菌学证实为革兰氏阴性菌感染，其中50%的患者为败血症。这三种抗菌方案效果相似，约55%的患者获得了良好的临床反应。与其他两种方案相比，头孢噻吩-妥布霉素组合的给药导致肾毒性的发生率显著更高。
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