妥布霉素的体外研究。
In vitro studies of tobramycin.
作者信息
Bodey G P, Stewart D
出版信息
Antimicrob Agents Chemother. 1972 Sep;2(3):109-13. doi: 10.1128/AAC.2.3.109.
Abstract
The in vitro activity of tobramycin was studied against 457 clinical isolates of gram-negative bacilli and 151 clinical isolates of gram-positive cocci. The vast majority of the gram-negative bacilli was inhibited by tobramycin at a concentration of 1.56 mug or less per ml. Only a few isolates of Staphylococcus aureus and no isolates of Streptococcus pyogenes or Diplococcus pneumoniae were susceptible to this drug. Tobramycin was generally more active than gentamicin sulfate against gram-negative bacilli, although organisms resistant to gentamicin sulfate were also resistant to tobramycin. The major difference between the two drugs was the greater activity of tobramycin against Pseudomonas aeruginosa.
摘要
研究了妥布霉素对457株革兰氏阴性杆菌临床分离株和151株革兰氏阳性球菌临床分离株的体外活性。绝大多数革兰氏阴性杆菌在每毫升1.56微克或更低浓度的妥布霉素作用下受到抑制。只有少数金黄色葡萄球菌分离株，而化脓性链球菌或肺炎双球菌分离株对该药物均不敏感。尽管对硫酸庆大霉素耐药的菌株也对妥布霉素耐药，但妥布霉素对革兰氏阴性杆菌的活性一般比硫酸庆大霉素更强。这两种药物的主要区别在于妥布霉素对铜绿假单胞菌的活性更强。
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