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兔肾中一种对前列腺素A具有特异性的15-羟基前列腺素脱氢酶。

A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney.

作者信息

Oien H G, Ham E A, Zanetti M E, Ulm E H, Kuehl F A

出版信息

Proc Natl Acad Sci U S A. 1976 Apr;73(4):1107-11. doi: 10.1073/pnas.73.4.1107.

DOI:10.1073/pnas.73.4.1107
PMID:4794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430209/
Abstract

Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not substrates for this enzyme. In agreement with published data, the 15-hydroxyprostaglandin dehydrogenase(s) derived from the kidney cortex were found to degrade all prostaglandins examined (PGE, PGF, PGA) in the presence of added cofactor NAD. Thus it is evident that in this species the kidney 15-hydroxyprostaglandin dehydrogenases are anatomically compartmentalized so that the papilla is able to metabpable of degrading E-, F-, and A-type prostaglandins by this metabolic pathway.

摘要

对兔肾乳头匀浆的可溶性部分进行检测，发现存在一种对A型前列腺素具有特异性的15-羟基前列腺素脱氢酶。E系列和F系列前列腺素不是该酶的底物。与已发表的数据一致，发现从肾皮质提取的15-羟基前列腺素脱氢酶在添加辅因子NAD的情况下能够降解所有检测的前列腺素（PGE、PGF、PGA）。因此很明显，在该物种中，肾脏的15-羟基前列腺素脱氢酶在解剖学上是分隔的，以至于乳头能够通过这种代谢途径代谢降解E型、F型和A型前列腺素。

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SYNTHESIS OF TRITIUM-LABELED PROSTAGLANDIN E-2 AND STUDIES ON ITS METABOLISM IN GUINEA PIG LUNG. 37. PROSTAGLANDINS AND RELATED FACTORS.氚标记前列腺素E-2的合成及其在豚鼠肺中代谢的研究。37. 前列腺素及相关因子。
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PROSTAGLANDINS AND RELATED FACTORS. 28. METABOLISM OF PROSTAGLANDIN E1 IN GUINEA PIG LUNG: THE STRUCTURES OF TWO METABOLITES.前列腺素及相关因子。28. 豚鼠肺中前列腺素E1的代谢：两种代谢产物的结构
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Selective passage of prostaglandins across the lung.前列腺素在肺中的选择性转运。
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The action of prostaglandin 15-hydroxydehydrogenase on various prostaglandins.前列腺素15-羟基脱氢酶对各种前列腺素的作用。
Biochim Biophys Acta. 1969 Dec 17;187(4):581-3. doi: 10.1016/0005-2760(69)90058-7.
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15-Hydroxy-prostanoate dehydrogenase. Prostaglandins as substrates and inhibitors.15-羟基前列腺素脱氢酶。以前列腺素为底物和抑制剂。
Eur J Biochem. 1969 Dec;11(2):386-9. doi: 10.1111/j.1432-1033.1969.tb00784.x.
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Br J Pharmacol. 1969 Nov;37(3):705-22. doi: 10.1111/j.1476-5381.1969.tb08509.x.
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Life Sci. 1974 Apr 16;14(8):1521-34. doi: 10.1016/0024-3205(74)90163-5.

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