Pyrhönen S, Johansson E
Lancet. 1975 Mar 15;1(7907):592-6. doi: 10.1016/s0140-6736(75)91880-2.
Altogether 173 patients with warts were under observation for at least 3 and in most cases 6 months. In 80% of the patients wart-virus antibodies were present and could be measured by immunodiffusion (I.D.) and in 20% also by complement-fixation (C.F.) techniques. The mean duration of the warts in patients with C.F. antibodies was 0-6 years and in the others 1-9 years. The occurence of C.F. antibodies (IgG) was associated with rapid healing; 75% of these patients were cured during the first 2 months of the observation period. In contrast, of the patients with antibodies measurable only by the I.D. technique (IgM and/or low titres of IgG), only 16% were cured during the first 2 months and they had a fairly constant cure-rate (approximately 9% per month) during the 6 months' observation period. The results indicate that the cure of warts is partly connected with immunological phenomena, especially with the presence of C.F. antibodies. In other cases wart regression may be mainly a non-immune process, perhaps due to a limited lifespan of wart cells.
共有173例疣患者接受了至少3个月的观察，大多数情况下观察了6个月。80%的患者存在疣病毒抗体，可通过免疫扩散（I.D.）法检测，20%的患者还可通过补体结合（C.F.）技术检测。有C.F.抗体的患者疣的平均持续时间为0 - 6年，其他患者为1 - 9年。C.F.抗体（IgG）的出现与快速愈合相关；这些患者中有75%在观察期的前2个月内治愈。相比之下，仅通过I.D.技术可检测到抗体（IgM和/或低滴度IgG）的患者中，只有16%在头2个月内治愈，并且在6个月的观察期内他们的治愈率相当稳定（约每月9%）。结果表明，疣的治愈部分与免疫现象有关，尤其是与C.F.抗体的存在有关。在其他情况下，疣的消退可能主要是一个非免疫过程，可能是由于疣细胞寿命有限。
