用肌苷普拉诺贝（免疫病毒素）治疗尖锐湿疣的初步研究。
Immunotherapy of genital warts with inosine pranobex (Imunovir): preliminary study.
作者信息
Mohanty K C, Scott C S
出版信息
Genitourin Med. 1986 Oct;62(5):352-5. doi: 10.1136/sti.62.5.352.
Abstract
One hundred and sixty five heterosexual men and women with genital warts were treated with inosine pranobex (Imunovir) or conventional treatment, or both. Inosine pranobex was found to be more effective in lesions of longer duration, whereas conventional treatment was more effective in genital warts of a shorter duration. Supplementation of conventional treatment with inosine pranobex increased the success rate from 41% to 94%. Immunological studies in 134 patients with genital warts showed an increased number of B cells in 21% of peripheral blood samples. Absence of major defects among circulating lymphocytes suggested that patients with genital warts may have a local immune reaction.
摘要
165名患有尖锐湿疣的异性恋男性和女性接受了异丙肌苷（免疫病毒素）治疗、传统治疗或两者联合治疗。结果发现，异丙肌苷对病程较长的损害更有效，而传统治疗对病程较短的尖锐湿疣更有效。在传统治疗基础上加用异丙肌苷可使成功率从41%提高到94%。对134例尖锐湿疣患者的免疫学研究显示，21%的外周血样本中B细胞数量增加。循环淋巴细胞中未发现主要缺陷，这表明尖锐湿疣患者可能存在局部免疫反应。
相似文献
1
Immunotherapy of genital warts with inosine pranobex (Imunovir): preliminary study.用肌苷普拉诺贝（免疫病毒素）治疗尖锐湿疣的初步研究。
Genitourin Med. 1986 Oct;62(5):352-5. doi: 10.1136/sti.62.5.352.
2
Immunotherapy of genital warts with inosine pranobex and conventional treatment: double blind placebo controlled study.用肌苷普拉诺贝和传统疗法对尖锐湿疣进行免疫治疗：双盲安慰剂对照研究。
Genitourin Med. 1988 Dec;64(6):383-6. doi: 10.1136/sti.64.6.383.
3
Comparative studies of inosine pranobex and acyclovir.肌苷普拉诺贝和阿昔洛韦的对比研究。
Am J Med. 1988 Aug 29;85(2A):7-9.
4
Treatment of first-attack genital herpes--acyclovir versus inosine pranobex.初发性生殖器疱疹的治疗——阿昔洛韦与异丙肌苷比较
Lancet. 1987 May 23;1(8543):1171-3. doi: 10.1016/s0140-6736(87)92144-1.
5
Suppression of frequently recurring genital herpes: acyclovir v inosine pranobex.频繁复发的生殖器疱疹的抑制作用：阿昔洛韦与异丙肌苷比较
Genitourin Med. 1989 Apr;65(2):103-5. doi: 10.1136/sti.65.2.103.
6
Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.异丙肌苷。对其药效学、药代动力学特性及治疗效果的初步综述。
Drugs. 1986 Nov;32(5):383-424. doi: 10.2165/00003495-198632050-00001.
7
[Treatment of genital warts and condyloma].
Ann Dermatol Venereol. 1988;115(2):239-46.
8
Imunovir in the treatment of immunodepression of diverse etiology.
Cancer Detect Prev Suppl. 1987;1:329-31.
9
Clinical and immunological assessment in HIV+ subjects receiving inosine-pranobex. A randomised, multicentric study.接受肌苷 pranobex 的 HIV 阳性受试者的临床和免疫学评估。一项随机、多中心研究。
Med Oncol Tumor Pharmacother. 1989;6(1):63-7. doi: 10.1007/BF02985225.
10
Isoprinosine in the treatment of genital warts.
Cancer Detect Prev. 1988;12(1-6):497-501.
引用本文的文献
1
A Review on Inosine Pranobex Immunotherapy for Cervical HPV-Positive Patients.关于肌苷普拉诺贝对宫颈HPV阳性患者免疫治疗的综述
Infect Drug Resist. 2021 Jun 2;14:2039-2049. doi: 10.2147/IDR.S296709. eCollection 2021.
2
Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases.肌苷普乐安：对抗多种病毒感染和非传染性疾病的关键药物。
Adv Ther. 2019 Aug;36(8):1878-1905. doi: 10.1007/s12325-019-00995-6. Epub 2019 Jun 5.
3
Functional characterization of CD4 and CD8 T cell responses among human papillomavirus infected patients with ano-genital warts.人乳头瘤病毒感染的肛门生殖器疣患者中CD4和CD8 T细胞反应的功能特征
Virusdisease. 2017 Jun;28(2):133-140. doi: 10.1007/s13337-017-0382-8. Epub 2017 Jun 13.
4
Immunotherapy of genital warts with inosine pranobex and conventional treatment: double blind placebo controlled study.用肌苷普拉诺贝和传统疗法对尖锐湿疣进行免疫治疗：双盲安慰剂对照研究。
Genitourin Med. 1988 Dec;64(6):383-6. doi: 10.1136/sti.64.6.383.
5
Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.异丙肌苷。对其药效学、药代动力学特性及治疗效果的初步综述。
Drugs. 1986 Nov;32(5):383-424. doi: 10.2165/00003495-198632050-00001.
本文引用的文献
1
Cryotherapy versus electrocautery in the treatment of genital warts.冷冻疗法与电灼术治疗尖锐湿疣的对比
Br J Vener Dis. 1981 Aug;57(4):273-4. doi: 10.1136/sti.57.4.273.
2
Thymus derived lymphocytes (T cells) in patients with genital warts.尖锐湿疣患者的胸腺来源淋巴细胞（T细胞）
Br J Vener Dis. 1984 Jun;60(3):186-8. doi: 10.1136/sti.60.3.186.
3
Immunocompetent cells in uterine cervical lesions of human papillomavirus origin.
Gynecol Obstet Invest. 1983;16(6):327-40. doi: 10.1159/000299290.
4
An indirect rosette technique for the identification and separation of human lymphocyte populations by monoclonal antibodies: a comparison with immunofluorescence methods.
Immunol Lett. 1983 May;6(5):241-6. doi: 10.1016/0165-2478(83)90012-3.
5
Drug-induced restoration of cutaneous delayed hypersensitivity in anergic patients with cancer.药物诱导癌症无反应患者皮肤迟发型超敏反应的恢复。
N Engl J Med. 1973 Aug 16;289(7):354-7. doi: 10.1056/NEJM197308162890707.
6
Wart-virus antibodies and the prognosis of wart disease.
Lancet. 1972 Dec 23;2(7791):1330-2. doi: 10.1016/s0140-6736(72)92776-6.
7
Immunophenotypes of lymphocytes in prospectively followed up human papillomavirus lesions of the cervix.前瞻性随访的子宫颈人乳头瘤病毒病变中淋巴细胞的免疫表型
Genitourin Med. 1985 Jun;61(3):190-6. doi: 10.1136/sti.61.3.190.
8
Adverse reactions to levamisole.左旋咪唑的不良反应。
Cancer Treat Rep. 1978 Nov;62(11):1721-30.
9
Decreased T cell levels in patients with warts.疣患者的T细胞水平降低。
Arch Dermatol. 1978 Feb;114(2):213-5.
10
Levamisole in a double-blind study: no effect on warts.
Acta Derm Venereol. 1977;57(5):449-54.
Zotero 插件