人类大脑的定量生长与发育
Quantitative growth and development of human brain.
作者信息
Dobbing J, Sands J
出版信息
Arch Dis Child. 1973 Oct;48(10):757-67. doi: 10.1136/adc.48.10.757.
Abstract
One hundred and thirty-nine complete human brains ranging in age from 10 weeks' gestation to 7 postnatal years, together with 9 adult brains, have been analysed in order to describe the human brain growth spurt quantitatively. The three major regions were examined for weight, DNA, cholesterol, and water content. The growth spurt period is much more postnatal than has formerly been supposed. The cerebellum has special growth characteristics; and there is a separate period from 10 to 18 weeks' gestation when adult neuronal cell number may largely be achieved. The implications of these findings for the vulnerability of developing brain are discussed.
摘要
为了定量描述人类大脑的生长突增，对139个完整的人类大脑进行了分析，这些大脑的年龄范围从妊娠10周直至出生后7岁，同时还分析了9个成人大脑。对三个主要区域的重量、DNA、胆固醇和含水量进行了检测。生长突增期比之前认为的更多地发生在出生后。小脑具有特殊的生长特征；在妊娠10至18周时有一个单独的时期，此时可能基本完成成体神经元细胞数量的增长。讨论了这些发现对发育中大脑易损性的影响。
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