Claas F H, Deelder A M
J Immunogenet. 1979 Jun;6(3):167-75. doi: 10.1111/j.1744-313x.1979.tb00342.x.
Mice of two congenic inbred strains C3H/Sn (H-2k) and C3H.B10 (H-2b) were infected with 100 Schistosoma mansoni cercariae. After the infection, the following parameters for the immunological response were studied: worm burden, mortality, antibody titre, spleen index, eosinophilia, delayed type of hypersensitivity and in vitro response to three S. mansoni antigen preparations. No difference in the worm burden and in the in vitro response to the antigen preparations of adult worm antigen, soluble egg antigens and the egg antigen MSA1, was found. The C3H.B10 mice showed a significantly higher mortality, antibody titre and delayed type of hypersensitivity while the C3H/Sn mice showed asignificantly higher spleen index and eosinophilia. This indicates that the H-2 region influences the course of an acute S. mansoni infection, whereas the susceptibility to the infection seems not to be influenced, as is shown by the worm burden.
将两个同源近交系C3H/Sn（H-2k）和C3H.B10（H-2b）的小鼠感染100条曼氏血吸虫尾蚴。感染后，研究了免疫反应的以下参数：虫负荷、死亡率、抗体滴度、脾脏指数、嗜酸性粒细胞增多、迟发型超敏反应以及对三种曼氏血吸虫抗原制剂的体外反应。未发现虫负荷以及对成虫抗原、可溶性虫卵抗原和虫卵抗原MSA1的抗原制剂的体外反应存在差异。C3H.B10小鼠的死亡率、抗体滴度和迟发型超敏反应显著更高，而C3H/Sn小鼠的脾脏指数和嗜酸性粒细胞增多显著更高。这表明H-2区域影响急性曼氏血吸虫感染的进程，而如虫负荷所示，对感染的易感性似乎不受影响。
