Jones J T, McCaffery D M, Kusel J R
Parasitology. 1983 Feb;86 (Pt 1):19-30. doi: 10.1017/s0031182000057139.
In order to determine whether a given H-2 haplotype has similar effects on responses to schistosomiasis mansoni on different genetic backgrounds, mice of 2 pairs of congenic strains (H-2b and H-2k on BALB/c and C57BL/10 backgrounds) were infected. Worm burdens, mortality, splenomegaly, tissue and faecal egg counts, and antibody titres to worm and egg antigens were measured. The genetic background had a major effect on the genesis of splenomegaly, on the deposition of eggs in the spleen, the maximum faecal egg count, the antibody titre to egg and worm antigens and the rate of generation of antibody response. The H-2 haplotype was shown to consistently influence the maximum faecal egg count and the antibody titres. Worm burden was not influenced by genetic differences between strains and mortality differences were not significant. The data presented here indicate that the effect of the major histocompatibility complex on responses to infection is greatly influenced by the genetic background on which it is expressed.
为了确定给定的H-2单倍型在不同遗传背景下对曼氏血吸虫病反应是否具有相似影响，对2对同源近交系小鼠（BALB/c背景的H-2b和C57BL/10背景的H-2k）进行了感染。测量了虫负荷、死亡率、脾肿大、组织和粪便虫卵计数以及针对虫体和虫卵抗原的抗体滴度。遗传背景对脾肿大的发生、脾脏中虫卵的沉积、粪便中最大虫卵计数、针对虫卵和虫体抗原的抗体滴度以及抗体反应的产生速率有重大影响。结果表明，H-2单倍型始终影响粪便中最大虫卵计数和抗体滴度。虫负荷不受品系间遗传差异的影响，死亡率差异不显著。此处呈现的数据表明，主要组织相容性复合体对感染反应的影响在很大程度上受其表达所依赖的遗传背景的影响。
