Dalle M, Pradier P, Essono-Ondo A, Delost P
Steroids. 1984 Nov;44(5):459-65. doi: 10.1016/s0039-128x(84)80005-7.
Cortisol metabolism appears to be active soon after birth in guinea-pigs. Indeed, plasma cortisol half-life measured in three day-old animals resembles that of adult guinea-pigs (48 min). The metabolic clearance rate (MCR) of plasma cortisol as measured by continuous infusions of 3H-cortisol in fetal and newborn guinea-pigs remained very low, increasing slowly and regularly during the perinatal period without abrupt change at birth. Whole cortisol MCR in fetus is presented as the resultant of the concomitant actions of three factors: transfer to the mother, fetal irreversible removal rate and placental metabolism. True fetal cortisol MCR could be dissociated from total cortisol MCR measured in fetus by comparing the ratios of other measured parameters in maternal and fetal plasmas. Until ten days post partum, cortisol MCR varied independently of body weight growth and reflected the maturation of catabolizing hepatic enzymes.
豚鼠出生后不久，皮质醇代谢似乎就很活跃。事实上，在三日龄动物中测得的血浆皮质醇半衰期与成年豚鼠相似（48分钟）。通过在胎儿和新生豚鼠中持续输注3H-皮质醇来测量血浆皮质醇的代谢清除率（MCR）仍然非常低，在围产期缓慢而有规律地增加，在出生时没有突然变化。胎儿的整体皮质醇MCR表现为三个因素共同作用的结果：向母体的转移、胎儿不可逆清除率和胎盘代谢。通过比较母体和胎儿血浆中其他测量参数的比率，可以将真正的胎儿皮质醇MCR与在胎儿中测得的总皮质醇MCR区分开来。直到产后十天，皮质醇MCR的变化与体重增长无关，反映了分解代谢肝酶的成熟。
