Kirby A W
J Gen Physiol. 1979 Jul;74(1):71-84. doi: 10.1085/jgp.74.1.71.
The effect of intravenous strychnine and the GABA antagonists picrotoxin and bicuculline upon the discharge pattern of center-surround-organized cat retinal ganglion cells of X and Y type were studied. Stimuli (mostly scotopic, and some photopic) were selected such that responses from both on and off-center cells were either due to the center, due to the surround, or clearly mixed. Pre-drug control responses were obtained, and their behavior following administration of the antagonists was observed for periods up to several hours. X-cell responses were affected in a consistent manner by strychnine while being unaffected by GABA antagonists. All observed changes following strychnine were consistent with a shift in center-surround balance of X cells in favor of the center. For Y-cell responses to flashing annuli following strychnine, there was either no shift or a relatively small shift in center-surround balance. Compared to X-cell responses to flashing lights, those of Y cells were very little affected by strychnine and in most cases were unaffected. It thus appears that glycine plays a similar role in receptive field organization of X cells as does GABA in Y cells (Kirby and Enroth-Cugell, 1976. J. Gen. Physiol. 68:465-484).
研究了静脉注射士的宁以及GABA拮抗剂印防己毒素和荷包牡丹碱对X型和Y型中心-周边组织化猫视网膜神经节细胞放电模式的影响。选择了刺激（大多为暗视条件下的，还有一些明视条件下的），使得来自中心型和周边型细胞的反应要么源于中心，要么源于周边，要么明显是混合的。获得了给药前的对照反应，并观察了拮抗剂给药后长达数小时的反应行为。士的宁以一致的方式影响X细胞反应，而GABA拮抗剂对其无影响。士的宁给药后观察到的所有变化都与X细胞中心-周边平衡向有利于中心的方向转变一致。对于士的宁给药后Y细胞对闪烁环形刺激的反应，中心-周边平衡要么没有变化，要么变化相对较小。与X细胞对闪光的反应相比，Y细胞的反应受士的宁影响很小，在大多数情况下不受影响。因此，甘氨酸在X细胞感受野组织中似乎起着与GABA在Y细胞中类似的作用（Kirby和Enroth-Cugell，1976年。《普通生理学杂志》68:465-484）。
