γ-氨基丁酸拮抗剂改变视杆驱动而非视锥驱动的猫视网膜神经节Y细胞感受野中心的空间总和。
Gaba-antagonists alter spatial summation in receptive field centres of rod- but not cone-drive cat retinal ganglion Y-cells.
作者信息
Kirby A W, Schweitzer-Tong D E
出版信息
J Physiol. 1981 Nov;320:303-8. doi: 10.1113/jphysiol.1981.sp013950.
Abstract
- When Y-type cat retinal ganglion cells were driven by cones, the i.v. administration of the GABA-antagonist picrotoxin failed to alter receptive field centre size. 2. This result is in marked contrast to our previous finding that when Y-cells were driven by rods, GABA-antagonists led to specific and reversible changes in centre size. 3. These results taken together suggest that for centre signals of Y-cells, the rod and cone pathways are pharmacologically distinct.
摘要
- 当用视锥细胞驱动Y型猫视网膜神经节细胞时，静脉注射GABA拮抗剂印防己毒素未能改变感受野中心大小。2. 这一结果与我们之前的发现形成显著对比，即当用视杆细胞驱动Y细胞时，GABA拮抗剂会导致中心大小发生特定且可逆的变化。3. 综合这些结果表明，对于Y细胞的中心信号，视杆细胞和视锥细胞通路在药理学上是不同的。
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