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照射移植的小鼠淋巴肉瘤对转移后续发展的影响。

The effect of irradiating a transplanted murine lymphosarcoma on the subsequent development of metastases.

作者信息

Sheldon P W, Fowler J F

出版信息

Br J Cancer. 1973 Dec;28(6):508-14. doi: 10.1038/bjc.1973.180.

Abstract

Mice were implanted with a lymphosarcoma on either the thorax or leg. Some of these tumours were given a single dose of 240 kV x-rays on reaching a predetermined size, whilst others were left unirradiated.Metastases developed in specific lymph nodes, depending on the position of the transplanted tumour, and were larger if the tumour had been irradiated than if not. The growth rate of metastases in the ipsilateral axillary lymph node was faster than that of the transplanted tumours, irrespective of the radiation dose the tumour had received.

摘要

将淋巴肉瘤植入小鼠的胸部或腿部。当其中一些肿瘤长到预定大小时,给予单次剂量的240 kV X射线照射,而其他肿瘤则不进行照射。转移瘤在特定的淋巴结中形成,具体取决于移植肿瘤的位置,并且接受过照射的肿瘤形成的转移瘤比未接受照射的更大。无论肿瘤接受何种辐射剂量,同侧腋窝淋巴结中转移瘤的生长速度都比移植肿瘤的生长速度快。

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