Sheldon P W
Br J Cancer. 1974 Nov;30(5):416-20. doi: 10.1038/bjc.1974.215.
A slowly growing solid sarcoma was implanted subcutaneously on the anterior chest wall of mice. On reaching a predetermined size the tumours were locally irradiated using 240 kV x-rays with single doses of 0, 2000 or 5000 rad. The mice were sacrificed 12 weeks after irradiation and examined for lung metastases, which were found to be less frequent in those mice whose implanted tumours had received the most irradiation.
将一个生长缓慢的实体肉瘤皮下植入小鼠的前胸壁。当肿瘤达到预定大小时,使用240 kV X射线对肿瘤进行局部照射,单剂量分别为0、2000或5000拉德。照射后12周处死小鼠并检查肺转移情况,发现植入肿瘤接受照射剂量最大的那些小鼠肺转移的发生率较低。