Tanaka N, Ohkawa T, Hiyama T, Nakajima A
J Pharmacol Exp Ther. 1983 Feb;224(2):424-30.
The ocular effects of two beta blocking drugs, carteolol and practolol, were assessed in beagle dogs. Practolol-treated dogs showed a tear flow reduction: histopathological examination showed lymphocytic infiltration in the lacrymal glands and electroretinogram showed a decrease in the amplitudes of the A + B-wave. By contrast, no drug-related abnormal changes were observed in carteolol-treated dogs. These results were thought to indicate that a tear flow measurement and electroretinogram examination should be used in the evaluation of the safety of beta blocking drugs.
在比格犬中评估了两种β受体阻滞剂（卡替洛尔和美多心安）的眼部效应。接受美多心安治疗的犬泪液分泌减少：组织病理学检查显示泪腺有淋巴细胞浸润，视网膜电图显示A+B波振幅降低。相比之下，接受卡替洛尔治疗的犬未观察到与药物相关的异常变化。这些结果被认为表明在评估β受体阻滞剂的安全性时应使用泪液分泌测量和视网膜电图检查。
