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乳鼠肠道乳糖酶活性：垂体切除和甲状腺切除的影响。

Intestinal lactase activity in the suckling rat: influence of hypophysectomy and thyroidectomy.

作者信息

Yeh K, Moog F

出版信息

Science. 1974 Jan 11;183(4120):77-9. doi: 10.1126/science.183.4120.77.

DOI:10.1126/science.183.4120.77
PMID:4808787
Abstract

Intestinal lactase activity, which is high in the infant rat intestine but falls to a low level by the end of the third week, fails to decline in animals hypophysectomized at the age of 6 days. Treating these animals with thyroxine lowers lactase activity to the control level at 24 days, but cortisone is only partly effective. Thyroidectomy at 6 days also results in persistence of high lactase activity; thyroxine again is more effective than cortisone in reducing activity. The thyroid gland appears to play a previously unsuspected role in intestinal maturation.

摘要

肠乳糖酶活性在幼鼠肠道中较高，但在第三周结束时降至低水平，而在6日龄时接受垂体切除的动物中该活性并未下降。用甲状腺素治疗这些动物可使24日龄时的乳糖酶活性降至对照水平，但皮质酮仅部分有效。6日龄时进行甲状腺切除也会导致高乳糖酶活性持续存在；甲状腺素在降低活性方面再次比皮质酮更有效。甲状腺似乎在肠道成熟过程中发挥了先前未被怀疑的作用。

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Science. 1974 Jan 11;183(4120):77-9. doi: 10.1126/science.183.4120.77.
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