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1
Further studies of gastric hypersecretion in chronic renal failure.慢性肾衰竭中胃分泌过多的进一步研究。
Br Med J. 1974 Jan 19;1(5898):96-8. doi: 10.1136/bmj.1.5898.96.
2
Inhibition by secretin of the gastric acid responses to meals and to pentagastrin in duodenal ulcer patients.十二指肠溃疡患者中，促胰液素对进餐及五肽胃泌素引起的胃酸反应的抑制作用。
Gut. 1973 Nov;14(11):842-6. doi: 10.1136/gut.14.11.842.
3
Effect of gastric hypersecretion on the canine duodenum.胃酸分泌过多对犬十二指肠的影响。
Scand J Gastroenterol. 1976;11(6):609-14.
4
Effect of cholecystokinin and secretin on gastric hypersecretion in a patient with the Zollinger-Ellison syndrome.
Aust N Z J Med. 1972 Nov;2(4):393-6. doi: 10.1111/j.1445-5994.1972.tb03943.x.
5
Effect of acid infusion into various levels of the intestine on gastric and pancreatic secretion in the cat.
Gut. 1969 Sep;10(9):749-53. doi: 10.1136/gut.10.9.749.
6
Pancreatic and gastric secretion in rats studied by means of duodenal and gastric perfusion.通过十二指肠和胃灌注法对大鼠胰腺和胃分泌的研究。
Scand J Gastroenterol. 1972;7(1):47-53. doi: 10.3109/00365527209180738.
7
Effects of parenteral secretin--cholecystokinin and of duodenal acid perfusion on gastric secretion in duodenal ulcer patients.胃肠外分泌素-胆囊收缩素及十二指肠酸灌注对十二指肠溃疡患者胃分泌的影响。
Am J Dig Dis. 1977 Apr;22(4):371-8. doi: 10.1007/BF01072196.
8
Secretin and cholecystokin-pancreozymin in combination in the inhibition of gastric acid secretion.促胰液素与缩胆囊素-促胰酶素联合抑制胃酸分泌。
Gut. 1971 Dec;12(12):968-72. doi: 10.1136/gut.12.12.968.
9
Effect of pentagastrin on cholecystokinin and secretin choleresis in the dog.五肽胃泌素对犬胆囊收缩素和促胰液素胆汁分泌的影响。
J Surg Res. 1974 Jul;17(1):26-9. doi: 10.1016/0022-4804(74)90163-2.
10
Gastric response to metiamide.胃对甲硫米特的反应。
Br Med J. 1974 May 11;2(5914):304-6. doi: 10.1136/bmj.2.5914.304.

引用本文的文献

1
Effect of metiamide on the response to secretin and cholecystokinin in man.甲硫米特对人体对促胰液素和缩胆囊素反应的影响。
Gut. 1975 Jan;16(1):33-5. doi: 10.1136/gut.16.1.33.
2
Gastric function and histology in chronic renal failure.慢性肾衰竭患者的胃功能与组织学
J Clin Pathol. 1979 Mar;32(3):208-13. doi: 10.1136/jcp.32.3.208.

本文引用的文献

1
Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia.由于胃分泌过多伴胰岛细胞增生导致的吸收不良和空肠溃疡。
Lancet. 1959 Jan 17;1(7064):120-3. doi: 10.1016/s0140-6736(59)90003-0.
2
[Comparison of the inhibitory effects of atropine & 2 synthetic parasympatholytics of the postinsulin & basal gastric secretion in man].
Acta Gastroenterol Belg. 1956 Dec;19(12):819-32.
3
Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas.空肠原发性消化性溃疡与胰腺胰岛细胞瘤相关。
Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8.
4
Acidity at different sites in the proximal duodenum of normal subjects and patients with duodenal ulcer.正常受试者和十二指肠溃疡患者近端十二指肠不同部位的酸度。
Gut. 1966 Oct;7(5):509-14. doi: 10.1136/gut.7.5.509.
5
Profile of pH, pressure, and potential difference at gastroduodenal junction in man.人体胃十二指肠连接处的pH值、压力和电位差概况。
Gastroenterology. 1965 Oct;49(4):364-71.
6
pH of the duodenum of patients with and without duodenal ulcers measured with a radiotelemetering capsule.使用无线电遥测胶囊测量有十二指肠溃疡和无十二指肠溃疡患者十二指肠的pH值。
Gastroenterology. 1969 Mar;56(3):476-82.
7
The Zollinger-Ellison syndrome with steatorrhea. I. Anticholinergic treatment followed by total gastrectomy and colonic interposition.伴有脂肪泻的佐林格-埃利森综合征。I. 抗胆碱能治疗后行全胃切除术及结肠间置术。
Gastroenterology. 1968 Dec;55(6):695-704.
8
Response to secretin in man.人类对促胰液素的反应。
Gastroenterology. 1968 Feb;54(2):197-209.
9
Quantitative aspects of synergism and inhibition of gastric acid secretion.胃酸分泌协同作用与抑制作用的定量研究
Gastroenterology. 1968 Apr;54(4):532-7.
10
Physiologic responses to gastric acid hypersecretion in Zollinger-Ellison syndrome.
Am J Dig Dis. 1968 Mar;13(3):191-203. doi: 10.1007/BF02236593.

慢性肾衰竭中胃分泌过多的进一步研究。

Further studies of gastric hypersecretion in chronic renal failure.

作者信息

Shepherd A M, Stewart W K, Thjodleifsson B, Wormsley K G

出版信息

Br Med J. 1974 Jan 19;1(5898):96-8. doi: 10.1136/bmj.1.5898.96.

DOI:10.1136/bmj.1.5898.96
PMID:4809815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1632936/
Abstract

The effect of medical treatment has been studied in four patients with end-stage renal failure who suffered from severe spontaneous gastric hypersecretion, associated with very low levels of intraduodenal pH in two cases. Atropine decreased the overnight gastric acid output, but the residual acid secretion and duodenal content of acid remained dangerously high in one of the patients. Secretin inhibited the basal gastric secretion of acid in all cases and converted the pH of the duodenal contents to alkaline. While atropine cannot be used to control the gastric hypersecretion, secretin may prove to be valuable in the therapeutic management of the gastric hypersecretion of patients with chronic renal failure.

摘要

对四名终末期肾衰竭患者进行了医学治疗效果的研究，这些患者患有严重的自发性胃酸分泌过多，其中两例十二指肠内pH值极低。阿托品降低了夜间胃酸分泌量，但其中一名患者的残余酸分泌和十二指肠酸含量仍处于危险的高水平。促胰液素在所有病例中均抑制了基础胃酸分泌，并使十二指肠内容物的pH值变为碱性。虽然阿托品不能用于控制胃酸分泌过多，但促胰液素可能在慢性肾衰竭患者胃酸分泌过多的治疗管理中被证明具有价值。