胃对甲硫米特的反应。
Gastric response to metiamide.
作者信息
Thjodleifsson B, Wormsley K G
出版信息
Br Med J. 1974 May 11;2(5914):304-6. doi: 10.1136/bmj.2.5914.304.
Abstract
Metiamide greatly reduced pentagastrin-stimulated and overnight secretion of acid and pepsin in 11 patients with duodenal ulcer and virtually abolished gastric secretion in three patients with gastric ulcer. The drug was equally effective when infused intravenously or intraduodenally. A therapeutic trial of Metiamide is warranted in diseases caused or aggravated by excess gastric secretion of acid and pepsin.
摘要
甲硫米特可显著减少11例十二指肠溃疡患者中由五肽胃泌素刺激引起的以及夜间的胃酸和胃蛋白酶分泌，在3例胃溃疡患者中几乎完全消除了胃酸分泌。该药物经静脉注射或十二指肠内注射时效果相同。对于由胃酸和胃蛋白酶分泌过多引起或加重的疾病，有必要对甲硫米特进行治疗试验。
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本文引用的文献
1
A method for estimating peptic activity in gastric contents.一种估计胃内容物中消化酶活性的方法。
Biochem J. 1948;42(1):104-9. doi: 10.1042/bj0420104.
2
Serial studies of gastric secretion in patients after highly selective (parietal cell) vagotomy without a drainage procedure for duodenal ulcer. I. Effect of highly selective vagotomy on basal and pentagastrin-stimulated maximal acid output.十二指肠溃疡患者在未行引流手术的高选择性（壁细胞）迷走神经切断术后胃液分泌的系列研究。I. 高选择性迷走神经切断术对基础胃酸分泌及五肽胃泌素刺激的最大胃酸分泌的影响
Gastroenterology. 1973 Jan;64(1):1-11.
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