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相似文献

1
Gastric response to metiamide.胃对甲硫米特的反应。
Br Med J. 1974 May 11;2(5914):304-6. doi: 10.1136/bmj.2.5914.304.
2
Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.甲硫米特对人五肽胃泌素刺激的胃酸和胃蛋白酶基础分泌的影响的相关方面。
Gut. 1975 Jul;16(7):501-8. doi: 10.1136/gut.16.7.501.
3
Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in man.组胺H2受体拮抗剂甲硫米特对人体胃对组胺、五肽胃泌素、胰岛素和蛋白胨餐反应的影响。
Am J Dig Dis. 1974 Jul;19(7):609-16. doi: 10.1007/BF01073015.
4
Comparison of intraduodenal and intravenous administration of amino acids on gastric secretion in healthy subjects and patients with duodenal ulcer.健康受试者和十二指肠溃疡患者十二指肠内和静脉注射氨基酸对胃酸分泌影响的比较。
Gut. 1978 Oct;19(10):859-64. doi: 10.1136/gut.19.10.859.
5
The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。
J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.
6
Inhibition of pentagastrin-stimulated and overnight gastric secretion by LM24056, a new phenothiazine-derived antisecretory drug.新型吩噻嗪衍生抗分泌药物LM24056对五肽胃泌素刺激的和夜间胃分泌的抑制作用
Lancet. 1981 Feb 28;1(8218):471-3. doi: 10.1016/s0140-6736(81)91852-3.
7
Metiamide and stimulated acid secretion from the isolated non-distended and distended mouse stomach.甲硫米特与离体未扩张和扩张小鼠胃的刺激酸分泌。
J Physiol. 1977 Apr;266(2):327-46. doi: 10.1113/jphysiol.1977.sp011770.
8
Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.组胺H2受体阻断对人体迷走神经诱导的胃酸分泌的影响。
Br Med J. 1974 Aug 31;3(5930):554-6. doi: 10.1136/bmj.3.5930.554.
9
Effects of metiamide on the human stomach.甲硫米特对人体胃部的影响。
Clin Sci Mol Med. 1975 Nov;49(5):445-58. doi: 10.1042/cs0490445.
10
Effect of cimetidine on pentagastrin-stimulated gastric acid and pepsin secretion before and after 6 weeks of cimetidine treatment.西咪替丁治疗6周前后，西咪替丁对五肽胃泌素刺激的胃酸和胃蛋白酶分泌的影响。
Scand J Gastroenterol. 1978;13(2):193-7. doi: 10.3109/00365527809181747.

引用本文的文献

1
Early clinical experience with cimetidine in duodenal ulcer patients.西咪替丁治疗十二指肠溃疡患者的早期临床经验。
Ir J Med Sci. 1976 Dec;145(1):172. doi: 10.1007/BF02938940.
2
Classification and biological distribution of histamine receptor sub-types. 1975.组胺受体亚型的分类及生物学分布。1975年。
Agents Actions. 1994 Dec;43(3-4):97-115; discussion 116. doi: 10.1007/BF01986677.
3
The effect of cimetidine on basal gastric acid secretion in the rat.西咪替丁对大鼠基础胃酸分泌的影响。
Br J Pharmacol. 1982 Aug;76(4):551-5. doi: 10.1111/j.1476-5381.1982.tb09253.x.
4
Clinical assessment of antisecretory drugs in man.人体抗分泌药物的临床评估。
Br J Clin Pharmacol. 1982 Jul;14(1):15-23. doi: 10.1111/j.1365-2125.1982.tb04929.x.
5
Complete inhibition of food-stimulated gastric acid secretion by combined application of pirenzepine and ranitidine.哌仑西平和雷尼替丁联合应用对食物刺激引起的胃酸分泌的完全抑制作用。
Gut. 1981 Jul;22(7):542-8. doi: 10.1136/gut.22.7.542.
6
Effect of metiamide on the response to secretin and cholecystokinin in man.甲硫米特对人体对促胰液素和缩胆囊素反应的影响。
Gut. 1975 Jan;16(1):33-5. doi: 10.1136/gut.16.1.33.
7
The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man.用甲硫米特进行组胺H2受体阻滞对人体血清胃泌素水平的影响。
Gut. 1975 Mar;16(3):186-7. doi: 10.1136/gut.16.3.186.
8
Early clinical experience with metiamide, a histamine H2-receptor antagonist, in patients with duodenal ulcer.组胺H2受体拮抗剂甲硫米特在十二指肠溃疡患者中的早期临床经验。
Am J Dig Dis. 1975 Dec;20(12):1135-41. doi: 10.1007/BF01070757.
9
Metiamide in the Zollinger-Ellison syndrome.甲硫米特治疗卓-艾综合征。
Am J Dig Dis. 1975 Dec;20(12):1123-30. doi: 10.1007/BF01070755.
10
Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.甲硫米特对人五肽胃泌素刺激的胃酸和胃蛋白酶基础分泌的影响的相关方面。
Gut. 1975 Jul;16(7):501-8. doi: 10.1136/gut.16.7.501.

本文引用的文献

1
A method for estimating peptic activity in gastric contents.一种估计胃内容物中消化酶活性的方法。
Biochem J. 1948;42(1):104-9. doi: 10.1042/bj0420104.
2
Serial studies of gastric secretion in patients after highly selective (parietal cell) vagotomy without a drainage procedure for duodenal ulcer. I. Effect of highly selective vagotomy on basal and pentagastrin-stimulated maximal acid output.十二指肠溃疡患者在未行引流手术的高选择性（壁细胞）迷走神经切断术后胃液分泌的系列研究。I. 高选择性迷走神经切断术对基础胃酸分泌及五肽胃泌素刺激的最大胃酸分泌的影响
Gastroenterology. 1973 Jan;64(1):1-11.
3
Inhibition of gastric secretion in man by metiamide: a new, orally active histamine H 2 -receptor antagonist.甲硫米特对人体胃酸分泌的抑制作用：一种新型口服活性组胺H2受体拮抗剂。
Gut. 1973 May;14(5):424.

胃对甲硫米特的反应。

Gastric response to metiamide.

作者信息

Thjodleifsson B, Wormsley K G

出版信息

Br Med J. 1974 May 11;2(5914):304-6. doi: 10.1136/bmj.2.5914.304.

DOI:10.1136/bmj.2.5914.304
PMID:4597122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1610965/
Abstract

Metiamide greatly reduced pentagastrin-stimulated and overnight secretion of acid and pepsin in 11 patients with duodenal ulcer and virtually abolished gastric secretion in three patients with gastric ulcer. The drug was equally effective when infused intravenously or intraduodenally. A therapeutic trial of Metiamide is warranted in diseases caused or aggravated by excess gastric secretion of acid and pepsin.

摘要

甲硫米特可显著减少11例十二指肠溃疡患者中由五肽胃泌素刺激引起的以及夜间的胃酸和胃蛋白酶分泌，在3例胃溃疡患者中几乎完全消除了胃酸分泌。该药物经静脉注射或十二指肠内注射时效果相同。对于由胃酸和胃蛋白酶分泌过多引起或加重的疾病，有必要对甲硫米特进行治疗试验。