胃对甲硫米特的反应。
Gastric response to metiamide.
作者信息
Thjodleifsson B, Wormsley K G
出版信息
Br Med J. 1974 May 11;2(5914):304-6. doi: 10.1136/bmj.2.5914.304.
Abstract
Metiamide greatly reduced pentagastrin-stimulated and overnight secretion of acid and pepsin in 11 patients with duodenal ulcer and virtually abolished gastric secretion in three patients with gastric ulcer. The drug was equally effective when infused intravenously or intraduodenally. A therapeutic trial of Metiamide is warranted in diseases caused or aggravated by excess gastric secretion of acid and pepsin.
摘要
甲硫米特可显著减少11例十二指肠溃疡患者中由五肽胃泌素刺激引起的以及夜间的胃酸和胃蛋白酶分泌，在3例胃溃疡患者中几乎完全消除了胃酸分泌。该药物经静脉注射或十二指肠内注射时效果相同。对于由胃酸和胃蛋白酶分泌过多引起或加重的疾病，有必要对甲硫米特进行治疗试验。
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