维生素A、妊娠与口服避孕药
Vitamin A, pregnancy, and oral contraceptives.
作者信息
Wild J, Schorah C J, Smithells R W
出版信息
Br Med J. 1974 Jan 12;1(5897):57-9. doi: 10.1136/bmj.1.5897.57.
It has been shown that women receiving oral contraceptives have increased levels of serum vitamin A. High vitamin A levels may constitute a teratogenic hazard and it has been suggested that women who conceive soon after discontinuing oral contraceptive therapy may be especially at risk to this hazard.We have confirmed a significant increase in vitamin A levels in women taking oral contraceptives. During early pregnancy there is no significant difference in vitamin A levels between women who have recently been taking oral contraceptives and those who have not. We have been unable to show that either taking oral contraceptives shortly before pregnancy or a high vitamin A level during the first trimester of pregnancy, comparable to that of a woman taking oral contraceptives, has any detrimental effect on the outcome of pregnancy. It seems unlikely that women who conceive soon after discontinuing oral contraception run any teratogenic risk from increased vitamin A levels.
研究表明，服用口服避孕药的女性血清维生素A水平会升高。高维生素A水平可能构成致畸风险，有人认为，停止口服避孕药治疗后不久怀孕的女性可能尤其面临这种风险。我们已经证实，服用口服避孕药的女性维生素A水平显著升高。在怀孕早期，近期服用口服避孕药的女性和未服用的女性之间维生素A水平没有显著差异。我们未能证明在怀孕前不久服用口服避孕药或在妊娠头三个月维生素A水平升高（与服用口服避孕药的女性相当）会对妊娠结局产生任何不利影响。停止口服避孕药后不久怀孕的女性似乎不太可能因维生素A水平升高而面临任何致畸风险。
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