Kaul B L
Mutat Res. 1979 Jul;67(3):239-47. doi: 10.1016/0165-1218(79)90018-1.
Experiments were designed to investigate the cytogenetic activity of some commonly used phenolic antioxidants, namely BHA, BHT, BMP and PG, all used widely to preserve and stablize food products rich in fats and oils. Barley and onion were used as test systems. The treatments reduced seed germination and induced a significant amount of seedling injury. Only PMP treatments produced a moderate amount of chromosomal aberrations while others failed to do so. Being strong antioxidants it was expected that these compounds would reduce the cytogenetic damage caused by the radiations. Contrary to expectations, however, a significant increase was observed in the radiation damage measured as seed and seedling lethality and chromosomal aberrations. Chemical post-treatments also increased the radiation damage. The damage was, however, reduced with ATP post-irradiation treatment.
实验旨在研究一些常用酚类抗氧化剂的细胞遗传活性，这些抗氧化剂即丁基羟基茴香醚（BHA）、二丁基羟基甲苯（BHT）、没食子酸丙酯（PG）和叔丁基对苯二酚（TBHQ），它们都广泛用于保存和稳定富含油脂的食品。大麦和洋葱被用作测试系统。这些处理降低了种子发芽率，并导致大量幼苗损伤。只有叔丁基对苯二酚处理产生了适量的染色体畸变，而其他处理则未产生。作为强抗氧化剂，预计这些化合物会减少辐射造成的细胞遗传损伤。然而，与预期相反，以种子和幼苗致死率以及染色体畸变衡量的辐射损伤显著增加。化学后处理也增加了辐射损伤。不过，辐照后用三磷酸腺苷（ATP）处理可减少损伤。
