Oka T
Science. 1974 Apr 5;184(4132):78-80. doi: 10.1126/science.184.4132.78.
Stiulation of milk-protein synthesis in mouse mammary epithelium in vitro requires insulin, hydrocortisone, and prolactin. The requirement for hydrocortisone can be replaced by spermidine. The possibility that spermidine mediates the effect of glucocorticoid is also supported by the observation that the cellular spermidine concentration increases before the accelerated synthesis of casein and alpha-lactalbumin.
体外刺激小鼠乳腺上皮细胞中的乳蛋白合成需要胰岛素、氢化可的松和催乳素。氢化可的松的需求可以被亚精胺替代。亚精胺介导糖皮质激素作用的可能性也得到了以下观察结果的支持：在酪蛋白和α-乳白蛋白加速合成之前，细胞内亚精胺浓度会升高。
