糖尿病酮症酸中毒中的脑递质前体和代谢产物。
Brain transmitter precursors and metabolites in diabetic ketoacidosis.
作者信息
Curzon G, Kantamaneni B D, Callaghan N, Sullivan P A
出版信息
J Neurol Neurosurg Psychiatry. 1982 Jun;45(6):489-93. doi: 10.1136/jnnp.45.6.489.
Patients studied during recovery from an episode of ketoacidotic diabetes had raised blood glucose, plasma free fatty acid and plasma free tryptophan concentrations. Plasma total tryptophan was decreased. Well controlled diabetics showed normal values. The ketoacidotic patients had increased lumbar CSF tryptophan and 5-hydroxyindoleacetic acid concentrations. Plasma tyrosine and CSF tyrosine and homovanillic acid concentrations were normal in both diabetic groups. The results are discussed in relation to somewhat similar findings in uraemic and hepatic encephalopathy and to changes in rats with streptozotocin diabetes.
在酮症酸中毒性糖尿病发作恢复期接受研究的患者，其血糖、血浆游离脂肪酸和血浆游离色氨酸浓度升高。血浆总色氨酸降低。血糖控制良好的糖尿病患者各项指标正常。酮症酸中毒患者腰椎脑脊液中的色氨酸和5-羟吲哚乙酸浓度升高。两组糖尿病患者的血浆酪氨酸、脑脊液酪氨酸和高香草酸浓度均正常。结合在尿毒症和肝性脑病中 somewhat similar findings 以及链脲佐菌素诱导糖尿病大鼠的变化对这些结果进行了讨论。 （注：原文中“somewhat similar findings”表述不太准确，推测可能是“某些相似的发现”之类的意思，但按要求不添加解释。）
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