晚期肾病中的脑递质前体和代谢产物
Cerebral transmitter precursors and metabolites in advanced renal disease.
作者信息
Sullivan P A, Murnaghan D, Callaghan N, Kantamaneni B D, Curzon G
出版信息
J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):581-8. doi: 10.1136/jnnp.41.7.581.
Abstract
Patients with chronic renal disease had low plasma total tryptophan but an abnormally high proportion of this was in the free state. The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleacetic acid. CSF tryptophan correlated better with plasma free than with plasma total tryptophan. Plasma and CSF tyrosine concentrations were normal but CSF homovanillic acid was raised especially in subjects with encephalopathy. The possible significance of these changes in advanced renal disease is discussed.
摘要
慢性肾病患者血浆总色氨酸水平较低，但其中处于游离状态的比例异常高。患有脑病的受试者血浆游离色氨酸、脑脊液色氨酸和脑脊液5-羟吲哚乙酸水平升高。脑脊液色氨酸与血浆游离色氨酸的相关性比与血浆总色氨酸的相关性更好。血浆和脑脊液酪氨酸浓度正常，但脑脊液高香草酸水平升高，尤其是在患有脑病的受试者中。本文讨论了晚期肾病中这些变化的可能意义。
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本文引用的文献
1
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J Biol Chem. 1963 Oct;238:3241-8.
2
Determination of total protein in spinal fluid with sulphosalicylic acid and trichloroacetic acid.用磺基水杨酸和三氯乙酸测定脑脊液中的总蛋白
Clin Chim Acta. 1960 Sep;5:757-61. doi: 10.1016/0009-8981(60)90020-6.
3
Binding of indole analogues to human serum albumin. Effects of fatty acids.吲哚类似物与人血清白蛋白的结合。脂肪酸的影响。
J Biol Chem. 1965 Nov;240(11):4235-43.
4
Hemodialysis and plasma amino acid composition in chronic renal failure.慢性肾衰竭中的血液透析与血浆氨基酸组成
Am J Clin Nutr. 1968 Jun;21(6):565-73. doi: 10.1093/ajcn/21.6.565.
5
Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis.游离血清色氨酸在控制脑内色氨酸水平和5-羟色胺合成中的可能作用。
Adv Biochem Psychopharmacol. 1974;11(0):119-31.
6
Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure.丹克拉和杜威法测定色氨酸的误差。修订程序。
Anal Biochem. 1974 Aug;60(2):621-5. doi: 10.1016/0003-2697(74)90275-9.
7
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Physiol Behav. 1972 Jan;8(1):143-6. doi: 10.1016/0031-9384(72)90142-4.
8
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