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医学研究中动物实验的替代方法。

Alternatives to animal experiments in medical research.

作者信息

Gowans J L

出版信息

Br Med J. 1974 Mar 23;1(5907):557-9. doi: 10.1136/bmj.1.5907.557.

Abstract

In laboratory work which involves the large-scale routine assay of biologically-active substances the sponsors of "alternative" (in vitro) methods and the scientists have a common aim: a reduction in the use of living animals. In vitro methods are usually more accurate, easier to perform, and cheaper. Animals are no longer required for the production of certain antiviral vaccines.Those engaged in medical research where new knowledge is being sought also need no incentive to develop in vitro methods because they make refined analysis possible. Nevertheless, such in vitro methods are usually not alternatives in the sense that they substitute for animals; they complement experiments on animals. A legal requirement "that no experiment on a living animal may be performed if the purpose of the experiment can be achieved by alternative means not involving an experiment on a living animal" would be unenforceable.

摘要

在涉及生物活性物质大规模常规检测的实验室工作中,“替代”(体外)方法的倡导者和科学家有着共同的目标:减少活体动物的使用。体外方法通常更准确、更易于操作且成本更低。某些抗病毒疫苗的生产不再需要动物。从事探索新知识的医学研究人员也无需激励去开发体外方法,因为这些方法能实现精细分析。然而,此类体外方法通常并非是替代动物的那种意义上的替代方法;它们是对动物实验的补充。“如果实验目的可以通过不涉及活体动物实验的替代方法实现,就不得进行活体动物实验”这一法律要求是无法强制执行的。

引用本文的文献

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In Vitro 3D Modeling of Neurodegenerative Diseases.神经退行性疾病的体外3D建模
Bioengineering (Basel). 2023 Jan 10;10(1):93. doi: 10.3390/bioengineering10010093.

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2
Immunological enhancement as studied by cell culture techniques.通过细胞培养技术研究免疫增强作用。
Annu Rev Microbiol. 1970;24:373-98. doi: 10.1146/annurev.mi.24.100170.002105.

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