Brickman H F, Beaudry P H
Can Med Assoc J. 1974 Mar 16;110(6):640-4.
The prevalence of sensitivity to atypical mycobacteria was found to be low in 2152 Montreal first-grade children tested with tuberculin and one of four atypical antigens randomly allocated. Forty-nine had positive reactions to an atypical antigen. PPD-G produced more reactions than PPD-A, -B or -K. In Greater Montreal there was a higher prevalence of sensitivity to atypical mycobacteria than in the two suburban areas studied. The range of this prevalence, standardized for the type of antigen, was from 0.86 to 2.92% according to region. The highest prevalence of sensitivity to any single atypical antigen, 5.3%, was found for PPD-G in Greater Montreal.Tuberculous infection was found in 1.35% of the children. Small tuberculin reactions (5 to 9 mm to stabilized PPD 5 TU) require clarification by differential tuberculin testing. More of them are caused by M. tuberculosis than by atypical mycobacteria in this particular age group and region.Routine BCG immunization is not indicated for the particular population studied; when given to individuals at risk, its effectiveness should not be impaired by atypical sensitivity at the low level found locally. Future BCG plans require more epidemiologic data.
在对2152名蒙特利尔一年级儿童进行结核菌素和四种非典型抗原之一（随机分配）检测时，发现对非典型分枝杆菌敏感的患病率较低。49名儿童对非典型抗原呈阳性反应。PPD-G产生的反应比PPD-A、-B或-K更多。在大蒙特利尔地区，对非典型分枝杆菌敏感的患病率高于所研究的两个郊区。根据地区不同，这种患病率（按抗原类型标准化）的范围为0.86%至2.92%。在大蒙特利尔地区，对任何单一非典型抗原敏感的最高患病率为5.3%（PPD-G）。在1.35%的儿童中发现了结核感染。小结核菌素反应（对稳定的PPD 5 TU为5至9毫米）需要通过鉴别结核菌素检测来明确。在这个特定年龄组和地区，由结核分枝杆菌引起的此类反应比非典型分枝杆菌更多。对于所研究的特定人群，不建议进行常规卡介苗免疫；当给予高危个体时，其有效性不应因当地发现的低水平非典型敏感性而受损。未来的卡介苗接种计划需要更多的流行病学数据。
