Johanson C E, Balster R L, Bonese K
Pharmacol Biochem Behav. 1976 Jan;4(1):45-51. doi: 10.1016/0091-3057(76)90174-x.
Rhesus monkeys surgically prepared with intravenous catheters were given 23 hr daily access to injection of either cocaine, d-amphetamine, 1-amphetamine, d-methamphetamine or diethylpropion on a fixed ratio 1 schedule of reinforcement for a maximum of 30 days. Responding was maintained by all these drugs but showed both day-to-day and hour-to-hour variability. The two animals self-administering 0.2 mg/kg/infusion cocaine died in less than 5 days. All 6 animals given access to 0.05 mg/kg/infusion d-amphetamine or 0.025 mg/kg/infusion d-methamphetamine also died, but tended to survive more days than animals exposed to cocaine. Three of the 5 animals whose responding was maintained by 0.5 mg/kg/infusion diethylpropion and one of the two animals whose responding was maintained by 0.05 mg/kg/infusion 1-amphetamine survived the entire 30 days despite high rates of intake. Food intake was initially decreased, but often returned to predrug levels and was not related to level of drug intake.
给通过手术植入静脉导管的恒河猴，每天23小时按固定比例1强化程序注射可卡因、右旋苯丙胺、左旋苯丙胺、甲基苯丙胺或二乙胺苯丙酮，最长持续30天。所有这些药物都能维持动物的反应，但反应表现出日变化和小时变化。两只自行注射0.2毫克/千克/次可卡因的动物在不到5天内死亡。所有6只可注射0.05毫克/千克/次右旋苯丙胺或0.025毫克/千克/次甲基苯丙胺的动物也死亡了，但它们存活的天数往往比接触可卡因的动物多。5只通过注射0.5毫克/千克/次二乙胺苯丙酮维持反应的动物中有3只，以及2只通过注射0.05毫克/千克/次左旋苯丙胺维持反应的动物中有1只，尽管摄入量很高，但仍存活了整个30天。食物摄入量最初减少，但通常会恢复到用药前的水平，且与药物摄入量无关。
