Muckle D S
Ann R Coll Surg Engl. 1974 Feb;54(2):72-7.
Heat (42 degrees C) exerted an inhibitory effect on the oxygen uptake of the rabbit VX2 carcinoma in vitro and led to a decrease in viability and growth potential of the cells as measured by vital dye uptake and their ability to produce tumours on injection into a host. Normal host tissue cells were unaffected by elevated temperatures. After heating in vivo, tumours showed an 80-95% reduction in volume, with marked necrosis of the tumour cells. Later, macrophage invasion and replacement fibrosis were evident. There was a 50% survival rate in animals treated by local heating and a 30% survival rate in those treated by total body heating, while all the control rabbits died at 10 weeks. The selective inhibitory effect of heat on cancer cells and its application to human neoplasms are discussed.
热（42摄氏度）对兔VX2癌的体外氧摄取产生抑制作用，并导致细胞活力和生长潜能下降，这通过活体染料摄取以及将其注射到宿主体内产生肿瘤的能力来衡量。正常宿主组织细胞不受温度升高的影响。体内加热后，肿瘤体积缩小80% - 95%，肿瘤细胞出现明显坏死。随后，巨噬细胞浸润和替代性纤维化明显。局部加热治疗的动物存活率为50%，全身加热治疗的动物存活率为30%，而所有对照兔在10周时死亡。文中讨论了热对癌细胞的选择性抑制作用及其在人类肿瘤中的应用。
