从缺乏必需脂肪酸的大鼠分离出的肝线粒体中的腺嘌呤核苷酸转运
Adenine nucleotide translocation in liver mitochondria isolated from rats deficient in essential fatty acids.
作者信息
Böhles H, Heird W C, Nicholson J F
出版信息
Nutr Metab. 1979;23(5):408-15. doi: 10.1159/000176286.
Adenine nucleotide content and adenine nucleotide transport were evaluated in rats deficient in essential fatty acids (EFA) and in control rats. ADP uptake by EFA-deficient mitochondria was altered in a manner similar to the alteration produced by treatment of normal mitochondria with uncoupler. The uptake of ATP by EFA-deficient mitochondria was more rapid than that of normal mitochondria, but similar to that of normal mitochondria treated with uncoupler (DNP). Both uptake of ADP and uptake of ATP by EFA-deficient mitochondria were atractyloside sensitive. Total adenine nucleotide content of liver mitochondria from EFA-deficient rats was similar to that of liver mitochondria from control animals, but the content of ATP in EFA-deficient mitochondria was significantly higher than that of normal mitochondria. There was a negative correlation between the concentration of linoleic acid in total mitochondria lipids and ATP content of mitochondria.
对缺乏必需脂肪酸（EFA）的大鼠和对照大鼠的腺嘌呤核苷酸含量及腺嘌呤核苷酸转运进行了评估。EFA缺乏的线粒体对ADP的摄取发生改变，其方式类似于用解偶联剂处理正常线粒体所产生的改变。EFA缺乏的线粒体对ATP的摄取比正常线粒体更快，但与用解偶联剂（二硝基苯酚，DNP）处理的正常线粒体相似。EFA缺乏的线粒体对ADP和ATP的摄取均对苍术苷敏感。EFA缺乏大鼠肝脏线粒体的总腺嘌呤核苷酸含量与对照动物肝脏线粒体的相似，但EFA缺乏线粒体中ATP的含量显著高于正常线粒体。线粒体总脂质中亚油酸浓度与线粒体ATP含量之间存在负相关。
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