Chesney R W, Jax D K
Pediatr Res. 1979 Jul;13(7):854-60. doi: 10.1203/00006450-197907000-00012.
Newborn Sprague-Dawley rat pups were found to have reduced net tubular reclamation of the beta-amino acid taurine in vivo. The reabsorption of this compound increased between the 2nd and 4th week of life and the excreted taurine fell despite a rise in glomerular filtration rate indicative of increased transport with maturation. Kidney cortex in vivo accumulated taurine from plasma against a large chemical gradient. Newborn cortex slices in vitro accumulated taurine to higher levels at steady state at less than 0.4 mM, but uptake was less efficient at higher taurine concentrations. Further metabolism of taurine by cortex slices was not found at any age. Accumulation in adult and newborn cortex was greatest at 10-15 mEa/liter K in the external medium. Slices from younger animals had slightly higher pH optima for uptake and temperature elevation increases uptake more in neonatal than in adult kidney.
新生斯普拉格-道利大鼠幼崽体内β-氨基酸牛磺酸的肾小管净重吸收减少。该化合物的重吸收在出生后第2周和第4周之间增加，尽管肾小球滤过率升高表明随着成熟转运增加，但牛磺酸排泄量仍下降。体内肾皮质从血浆中逆着大的化学梯度积累牛磺酸。体外新生皮质切片在稳态时，牛磺酸浓度低于0.4 mM时积累到更高水平，但在较高牛磺酸浓度下摄取效率较低。在任何年龄都未发现皮质切片对牛磺酸有进一步代谢。在外部培养基中钾浓度为10 - 15 mEa/升时，成年和新生皮质中的积累量最大。年幼动物的切片摄取的最适pH值略高，温度升高时新生肾比成年肾摄取增加更多。
