Carroll M E, Meisch R A
Psychopharmacology (Berl). 1978 Dec 8;59(3):225-9. doi: 10.1007/BF00426626.
Drinking of etonitazene HCI was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (microgram/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.
在三只恒河猴身上进行了为期每日3小时的实验，研究它们对盐酸依托尼秦的饮用情况。随着药物浓度的增加，液体供应量减少，而依托尼秦摄入量（微克/千克体重）增加。随着固定比率（FR）要求的提高，反应速率增加，液体供应量略有下降。当用水替代药物时，在几个实验阶段中反应大幅增加，随后缓慢下降至低速率。当重新引入依托尼秦时，反应突然增加到之前的药物水平。这些数据表明，恒河猴口服依托尼秦时，它可以作为一种阳性强化物。
