Michel F B, Guendon R, d'Hinterland L D, Pinel A M, Préault M
Nouv Presse Med. 1975 Feb 1;4(5):327-31.
The current possibility of measuring at one and the same time serum IgA and sputum SIgA, has led to precision in knowledge of IgA deficits in respiratory pathology. The authors report 21 cases detected in a group of 1000 patients (adults, adolescents and children), suffering from various chronic respiratory disorders and who had either total deficits in serum and sputum IgA (6 cases) or partial deficits (15 cases - mixed [5], serum IgA [5i1, sputum IgA [5]. In 9 cases the assoicated respiratory disorder was bronchiectasis, in 7 recurrent rhino-tracheo-bronchitis and in 5 asthma. In no cases were any extra-respiratory manifestations noted, in particular digestive disturbance or auto-immune disease. In some cases there was an associated deficit in IgE and, much less commonly, in IgG or M. Cellular immunity was not altered. The authors then discuss the place of IgA and SIgA deficitis in the pathogenesis of chronic respiratory pathology as well as their substitutive treatment using natural human immunoglobulins and the results thereof.
目前能够同时检测血清IgA和痰液分泌型IgA，这使得在了解呼吸道疾病中IgA缺乏情况方面更加精确。作者报告了在1000例患者（成人、青少年和儿童）群体中检测到的21例病例，这些患者患有各种慢性呼吸道疾病，血清和痰液IgA存在完全缺乏（6例）或部分缺乏（15例——混合型[5例]、血清IgA缺乏[5例]、痰液IgA缺乏[5例]）。9例患者合并的呼吸道疾病为支气管扩张，7例为复发性鼻-气管-支气管炎，5例为哮喘。未发现任何呼吸道外表现，尤其是消化系统紊乱或自身免疫性疾病。部分病例还合并有IgE缺乏，而IgG或IgM缺乏则更为少见。细胞免疫未受影响。作者随后讨论了IgA和分泌型IgA缺乏在慢性呼吸道疾病发病机制中的地位，以及使用天然人免疫球蛋白进行替代治疗及其结果。
