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施万细胞特性。II. 退变神经中吞噬细胞的身份。

Schwann cell properties. II. The identity of phagocytes in the degenerating nerve.

作者信息

Liu H M

出版信息

Am J Pathol. 1974 May;75(2):395-416.

PMID:4823404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1910823/
Abstract

The present study was undertaken to identify the cells from which phagocytes originate following traumatic injury to the sciatic nerves in rats. The morphologic evolution of the phagocytes was correlated daily with changes in axon, myelin, Schwann cell and neurilemmal tube at light and electron microscopic levels. Autoradiography with tritiated thymidine was employed to label the proliferative cells immediately before and following the injury. The result indicated that degeneration of Schwann cells occurred with the onset of myelin breakdown and that the degenerated products of myelin, axon and Schwann cells were removed by macrophages. While most of the macrophages were originally blood monocytes, some were derived from vascular pericytes. They penetrated the neurilemmal tubes on the third postoperative day and began engulfing first the Schwann cells and then the myelin and axons. Having filled their cytoplasm with debris, some macrophages moved out of the neurilemmal tube while others remained temporarily inside the envelopes formed by the persisting neurilemmal tubes-thus the macrophages can inherit a basal lamina from degenerated Schwann cells.

摘要

本研究旨在确定大鼠坐骨神经创伤性损伤后吞噬细胞的起源细胞。在光镜和电镜水平上，每天将吞噬细胞的形态演变与轴突、髓鞘、施万细胞和神经膜管的变化进行关联。采用氚标记胸腺嘧啶核苷进行放射自显影，以在损伤前后立即标记增殖细胞。结果表明，随着髓鞘分解的开始，施万细胞发生变性，髓鞘、轴突和施万细胞的变性产物被巨噬细胞清除。虽然大多数巨噬细胞最初是血液中的单核细胞，但有些来源于血管周细胞。它们在术后第三天穿透神经膜管，开始先吞噬施万细胞，然后吞噬髓鞘和轴突。一些巨噬细胞的细胞质充满碎片后，移出神经膜管，而另一些则暂时留在由残留神经膜管形成的包膜内——因此巨噬细胞可以从退化的施万细胞继承基底膜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/88bf339c4d13/amjpathol00475-0198-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/4d0e2a4c7c52/amjpathol00475-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/54b5d9fa277e/amjpathol00475-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/f47d1b70abeb/amjpathol00475-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/f2b0e43cc75e/amjpathol00475-0197-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/d9f693a14b4a/amjpathol00475-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/b444213970be/amjpathol00475-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/88bf339c4d13/amjpathol00475-0198-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/4bb9372c3fd0/amjpathol00475-0199-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/f95351adb9f7/amjpathol00475-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/66ea6864a6c5/amjpathol00475-0201-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/1358f9e68ca2/amjpathol00475-0202-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/4a8e33a8760e/amjpathol00475-0203-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/4d0e2a4c7c52/amjpathol00475-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/54b5d9fa277e/amjpathol00475-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/f47d1b70abeb/amjpathol00475-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/f2b0e43cc75e/amjpathol00475-0197-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/d9f693a14b4a/amjpathol00475-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/b444213970be/amjpathol00475-0198-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b4/1910823/88bf339c4d13/amjpathol00475-0198-b.jpg

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