Plasma protein displacement interactions are rarely of clinical significance.

Drug interactions in general have been overemphasized with respect to both frequency and clinical importance. Interactions allegedly based on displacement of highly protein-bound drugs from plasma proteins are particularly misunderstood and the evidence supporting such interaction is typically incomplete. In those interactions where displacement has been most convincingly shown and a clinically important consequence ensues, an additional interaction mechanism has been present. On theoretical grounds such simple displacement interactions are not likely to be common, easy to detect or serious. If such interactions occur they will be transient.