前列腺素B1的聚合物衍生物PGBx的研究：I. PGBx的合成与纯化。
Studies on PGBx, a polymeric derivative of prostaglandin B1: I. Synthesis and purification of PGBx.
作者信息
Polis B D, Kwong S, Polis E, Nelson G, Shmukler H W
出版信息
Physiol Chem Phys. 1979;11(2):109-23.
PGBx, a new polymeric derivative of PGB1, previously was shown to (a) restore oxidative phosphorylation to degraded isolated rat liver mitochondria in vitro and (b) to reverse the effects of cardiogenic ischemia in monkeys and cerebral ischemia in rabbits. This report describes in detail the synthesis and purification of PGBx via PGB1, starting with azelaic acid. Details of the in vitro mitochondrial assay are also reported. Purified PGBx exhibiting maximal reactivation of mitochondrial phosphorylation has a mean molecular weight of 2350. Yield of PGBx based on azelaic acid is 4% and based on PGB1 is 25%.
PGBx是PGB1的一种新型聚合物衍生物，此前已表明它能：（a）在体外使降解的离体大鼠肝线粒体恢复氧化磷酸化，以及（b）逆转猴子的心源性缺血和兔子的脑缺血效应。本报告详细描述了以壬二酸为起始原料，通过PGB1合成和纯化PGBx的过程。还报告了体外线粒体测定的细节。表现出线粒体磷酸化最大再激活作用的纯化PGBx的平均分子量为2350。基于壬二酸的PGBx产率为4%，基于PGB1的产率为25%。
Zotero 插件